腰椎术后应用低分子肝素抗凝与硬膜外血肿形成的关联性研究

Association of low molecular weight heparin anticoagulation and epidural hematoma formation application after lumbar surgery

目的探讨腰椎术后硬膜外血肿形成与应用低分子肝素抗凝是否存在关联性。方法我科自2008-10起所有腰椎手术患者术后6 h皮下注射低分子量肝素钙注射液以预防深静脉血栓,将2008-10-2013-08患者作为治疗组,2003-08-2008-10患者作为对照组,统计两组硬膜外血肿发生率,分析应用低分子肝素与硬膜外血肿发生是否存在关联性。结果治疗组1128例患者,7例出现硬膜外血肿,发生率0.62%,对照组1060例患者,6例出现硬膜外血肿,发生率0.56%,结果 P>0.05,两组数据无显著性差异。结论腰椎术后硬膜外血肿形成与应用低分子肝素抗凝无直接关系。

Objective To investigate the relevance between postoperative lumbar epidural hematoma formation and application of low molecular weight heparin. Methods In our hospital from October 2008 onwards,all patients were subcutaneously injected low molecular weight heparin 6 hours after lumbar operation to prevent deep vein thrombosis. From October 2008 to August 2013,the cases were enrolled in the treatment group,from August 2003 to October 2008,the pa- tients were taken as the control group. The incidence rate of epidural hematoma in two groups was recorded,and the relationship between application of low molecular weight heparin and the occur- rence of epidural hematoma was analyzed. Results Of 1128 cases in the treatment group,7 cases occurred epidural hematoma,the incidence rate was 0.62%. of 1060 cases in the control group,6 cases occurred epidural hematoma,the incidence rate was 0.56%,the difference was not significant between the two groups （P〉0.05）. Conclusion Postoperative lumbar epidural hematoma formation has no direct relationship with the application of low molecular weight heparin.