PRR11蛋白在人胰腺癌中的表达及其意义

The expression and significance of PRR11 protein in human pancreatic carcinoma

背景与目的:近期研究发现,新基因PRR11在肺癌和胃癌中表达异常,推测可能与肿瘤进展有关。本研究探讨PRR11蛋白在人胰腺癌中的表达,并探讨其与胰腺癌临床病理参数之间的关系。方法:采用免疫组织化学SP法检测32例人胰腺癌组织、20例癌旁组织和6例正常胰腺组织中的PRR11蛋白的表达,并采用x^2检验分析PRR11蛋白的表达水平与临床病理参数(年龄、性别、肿瘤大小、肿瘤部位、分化程度、淋巴结转移和TNM分期)之间的关系。结果:PRR11蛋白在胰腺癌组、癌旁组织组和正常胰腺组织组的阳性表达率分别为78.1%(25/32)、5.0%(1/20)和0.0%(0/6),胰腺癌组的表达显著高于癌旁组织组及正常胰腺组织组(P<0.05),其在胰腺癌组织中的表达情况与分化程度、TNM分期有关(P<0.05),但与年龄、性别、肿瘤大小、肿瘤部位、有无淋巴结转移无关(P>0.05)。生存分析显示,PRR11蛋白阳性组患者的生存率低于阴性组(P<0.05)。结论:检测PRR11蛋白在胰腺癌中的表达,有望成为判断胰腺癌预后的一个指标。

Background and purpose： Recent studies have shown that, the new gene PRR11 had abnormal expression in lung cancer, stomach cancer, speculated that it might be correlated with tumor progression. This study aimed to detect the expression of PRR11 protein in human pancreatic carcinoma, and to analyze the relationship between PRR11 protein level and the clinical pathological parameters of pancreatic carcinoma. Methods： Immunohistochemistry （SP） method was used to detect the expression of PRR11 protein in 32 cases of human pancreatic cancer tissues, 20 cases of paracancerous tissues and 6 cases of normal pancreatic tissue. Chi Square test was used to analyze the relationship between the expression levels of PRR11 protein and the clinical pathological parameters （age, gender, the size of tumor, the location of tumor, differentiation, lymph node metastasis and TNM stage）. Results：The positive expression rates of PRR11 protein in pancreatic cancers, paracancerous tissues and normal pancreatic tissues were 78.1%（25/32）, 5.0%（1/20） and 0.0%（0/6）, respectively. The expression level of PRR11 in pancreatic cancer tissues was significantly higher than those in paracan-cerous tissues or normal tissues. The positive expression rate of PRR11 protein in pancreatic carcinoma was significantly associated with cell differentiation degree and TNM stage （P〈0.05）, but not associated with patient age, gender, the size of tumor, the location of tumor and lymph node metastasis （P〉0.05）. Survival analysis demonstrated that the survival rate in the patients with PRR11 protein positive expression was significantly lower than the patients with negative expression （P〈0.05）. Conclusion：PRR11 protein can be a possible prognostic indicator of pancreatic cancer.