干细胞niche在心脏干细胞稳态维持中的作用

ROLE OF STEM CELL NICHES IN MAINTAINING CARDIAC STEM CELLS HOMEOSTASIS

目的综述干细胞niches(stem cell niches,SCNs)在心脏干细胞(cardiac stem cells,CSCs)稳态维持中的作用,并展望其应用前景。方法广泛查阅近十年来关于心脏SCNs(cardiac SCNs,CSCNs)的文献,分析其组成细胞、细胞外基质及分泌因子在CSCs稳态维持中的作用,并进行综述。结果研究表明,CSCNs能延缓CSCs老化,保护其不受外因损害,保持干性稳定,并提高纯净度和数量,但作用机制尚不完全清楚。结论 CSCNs在CSCs干性稳定的维持以及纯化、扩增方面具有良好应用前景,有待进一步深入研究。

Objective To review the role of stem cell niches in maintaining cardiac stem cells homeostasis, and to foresee its prospects. Methods The literature on cardiac stem cells niches was extensively reviewed. The roles of stem cell niches components, extracellular matrix, and secretory factors in maintaining cardiac stem cell homeostasis were analysed and reviewed. Results Lots of experiments reveal that stem cell niches are able to delay the aging of cardiac stem cells, protect from external damage, keep stem properties, and improve the purity and quantity. However, the mechanism is not fully understood. Conclusion The stem cell niches have a very bright application prospect in homeostasis, purification, and amplification for the cardiac stem cells, and it needs further study.