医用海藻酸基衍生材料的研究进展

PROGRESS OF ALGINATE DERIVATIVES BASED ON BIOMEDICAL MATERIALS

目的总结医用海藻酸基衍生材料的研究现况及其作为新型医疗产品开发需关注的问题。方法基于对国内外医用海藻酸基衍生材料制备及应用研究的广泛调研,综合分析其研发现况、进展及存在问题。结果海藻酸基衍生材料具有多条衍生化途径,如交联、硫酸化、生物因子衍生化反应、疏水改性以及接枝共聚等。多种海藻酸基衍生材料具有良好结构和功能仿生性能,可用于组织工程支架、人工器官制造以及药物缓释等领域,但仍需要系统的应用基础研究数据提供风险管理依据。结论海藻酸基衍生材料作为医用新产品的开发具有良好可行性,但必须系统评价并验证其安全性、有效性和适宜性。

Objective To summarize the current research status of alginate derivatives based on biomedical materials, and analyze several key points as novel clinical products. Methods The general preparation and application methods of alginate derivatives based on biomedical materials at home and abroad were reviewed. The present status and problems were analyzed. Results The derivation methods to prepare alginate derivatives include crosslink, sulfation, biological factors derivatization, hydrophobic modification, and graft copolymerization. With excellent bionic performance of structure and properties, many alginate derivatives are available for tissue engineering scaffolds, artificial organs, and drug delivery systems etc. However, more systematic applied basic research data should be collected and statistically analyzed for risk managements. Conclusion Alginate derivatives have good feasibility as novel medical products, meanwhile, systematic evaluation and verification should be executed for their safety, effectiveness, and suitability.