三阴性乳腺癌中EGFR、CK5/6的表达及临床意义

Expression and Clinical Significance of EGFR、CK5/6 in Triple Negative Breast Cancer

目的:检测三阴性乳腺癌组织中EGFR、CK5/6的表达情况,探讨二者与三阴性乳腺癌患者临床与病理特征之间的关系。方法:回顾性分析94例三阴性乳腺癌患者的临床及病理资料,应用PV-9000免疫组化三步法检测EGFR、CK5/6在三阴性乳腺癌组织中的表达情况,分析二者与患者临床及病理指标之间的关系。结果:1EGFR、CK5/6在三阴性乳腺癌组织中的表达率分别为66.0%,74.5%;且二者的表达有关联性(r=0.287,P<0.05)。2EGFR的表达与年龄、肿瘤大小、组织学分级、民族、ki-67等临床及病理指标之间无统计学意义(P>0.05),在淋巴结有转移组及临床分期Ⅲ期组的表达率明显升高,差异有统计学意义(P<0.05);CK5/6的表达与淋巴结转移有关,而与其他临床病理指标无关,有淋巴结转移组CK5/6的表达率高于无转移组,差异有统计学意义(P<0.05)。结论:1在三阴性乳腺癌中,EGFR与CK5/6表达率高,二者表达趋于一致。2EGFR、CK5/6的高表达率与淋巴结转移有关,临床分期III期者EGFR阳性表达率高,二者可能与三阴性乳腺癌预后不良有关。

Objective：To detect the expression of EGFR,CK5/6 in triple negative breast cancer,furthermore to investigate their relationship with clinicopathological index. Methods：Expressions of EGFR,CK5/6 were detected in 94 cases of triple negative breast cacer tissues by PV-9000 immunohistochemical methods.Meanwhile,the relationship between the two indicators and clinicopathological index was analyzed. Results：（1）The expression of EGFR,CK5/6 in triple negative breast cacer were 66.0%,74.5% respectively.And expression of EGFR was correlation with CK5/6（r=0.287,P〈0.05）, they have the same expression trend.（2）The expression of EGFR was no correlation with age,tumor size,histological grade,nation,expression of ki-67（P〉0.05）, but it was much higher in？lymph node？metastasis group？and？ clinical stageⅢ？group, the difference was statistically significant（P〈0.05）,CK5/6 was related with lymph node metastasis, which ？expression in？lymph node？metastasis group was obviously higher than？non metastasis group（P〈0.05）.Conclusion：（1） In the triple negative breast cancer, EGFR and CK5 / 6 showed high expression, and they have the same expression trend.（2） The expression of EGFR and CK5/6 were significantly related with lymph node metastasis,and EGFR also related with clinical stages, which indicates that they may be related to poor prognosis of triple negative breast cancer.