肝纤四项联合血小板检测在诊断肝纤维化中的价值

Value on Diagnosis of Hepatic Fibrosis in Co-detection of Four Indicators and Platelet Counts

目的:探讨肝纤四项(透明质酸HA、Ⅲ型前胶原PCIII、Ⅳ型胶原IV-C、层粘连蛋白LN)联合血小板(PLT)检测对诊断肝病患者肝纤维化的临床价值及意义。方法:对150例经肝组织学证实的肝纤维化患者,以及100例经肝组织学证实没有肝纤维化的健康人,检测肝纤四项及血小板。比较肝纤维化者与健康人之间的肝纤四项及PLT。同时计算各单项指标及联合后在诊断肝纤维化方面的敏感性及特异性。结果:HA、PCIII、IV-C、LN在肝纤维化病人均明显高于健康人(P<0.01)。PLT在肝纤维化病人明显低于健康人(P<0.01)。肝纤四项组合诊断肝纤维化的灵敏度为88%,特异度为100%;肝纤四项联合血小板诊断肝纤维化的灵敏度为95.33%,特异度为100%。结论肝纤四项联合血小板检测可以提高肝纤维化诊断的敏感性。

Objective： To discussion the clinical value and significance of the co-detection of four indicators composed of hyaluronic acid HA, type III procollagen PCIII, collagen IV-C, laminin LN and platelet（PLT）count for the diagnosis of hepatic fibrosis. Methods Four indicators and PLT were measured in 150 cases with hepatic fibrosis group by hepatic histologyconfirmed and 100 cases from normal control group. To comparison the sensitivity and specificity between each index in diagnosis of hepatic fibrosis.Results HA,PCIII, IV-C,LN in hepatic fibrosis cases were significantly higher than the normal control group（p〈0.01）. PLT in hepatic fibrosis patients was significantly lower than the normal control group（p〈0.01）. The sensitivity and specificity of four indicators were 88% and 100% in diagnosis of hepatic fibrosis.The sensitivity and specificity of the co-detection of four indicators and PLT were 95.33% and 100%in diagnosis of hepatic fibrosis.Conclusion The co-detection of four indicators and PLT can improve the sensitivity in the diagnosis of hepatic fibrosis.