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miR-124在肿瘤研究中的进展 被引量：4

Advance of miR-124 in neoplasm research
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摘要 MicroRNA(miRNA)是一类在生物体内广泛表达的非编码小分子RNA,不仅参与调节生物体的生长发育,还与包括肿瘤在内的多种疾病的发生发展密切相关。miR-124就是其中之一,它是一个高度保守的抑癌miRNA。研究发现miR-124在多种肿瘤中均表达下调,已被证实在该类肿瘤的发生、发展以及预后中起着重要作用。 MicroRNA （miRNA） is a class of short non-coding RNA molecules, which diversely regulate gene expres- sion in organisms. MiRNAs have been found to perform an essential role not only in various biologic processes, but also in abnormal state including the occurrence and development of neoplasm, miR- 124, which is highly con- served, is down-expressed in various human neoplasm and is closely related to the occurrence, development and prognosis of neoplasm, as the key anti-oncogenic component.
作者 钟阿红 许希中 余进进 吴亦波
机构地区 苏州大学附属第四医院妇产科 江南大学附属医院 无锡市第四人民医院妇产科 无锡市第四人民医院生殖中心
出处 《基础医学与临床》 CSCD 2015年第4期531-535,共5页 Basic and Clinical Medicine
基金 江苏省自然科学基金(BK20140170) 无锡市科技计划项目(CSE31N1316)
关键词 microRNA(miRNA) miR-124 功能 肿瘤 microRNA （miRNA） miR-124 function neoplasm
分类号 R730.2 [医药卫生—肿瘤]
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  • 1Gupta GP, Massague J. Cancer metastasis: building a framework [J]. Cell, 2006,127(4):679-695.
  • 2Nicoloso MSI Spizzo R, Shimizu M, et al. MicroRNAs--the micro steering wheel of turnout metastases [J]. Nat Rev Cancer, 2009,9(4):293-302.
  • 3Ma L, Weinberg RA. Micromanagers of malignancy: role of microRNAs in regulating metastasis [J]. Trends Genet 2008,24 (9):448-456.
  • 4Barrel DP. MicroRNAs: genomics, biogenesis, mechanism, and function [J]. Cell, 2004,116(2):281-297.
  • 5Valastyan S, Reinhardt F, Benaich N, et al. A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis [J]. Cell, 2009,137(6):1032-1046.
  • 6Baylin SB, Ohm JE. Epigenetic gene silencing in cancer--a mechanism for early oncogenic pathway addiction? [J]. Nat Rev Cancer, 2006,6(2): 107-116.
  • 7Khraiwesh B, Arif MA, Seumel GI, et al. Transcriptional control of gene expression by microRNAs [J]. Cell, 2010,140(1):111- 122.
  • 8Seitz H, Youngson N, Lin SP, et al. Imprinted microRNA genes transcribed antisense to a reciprocally imprinted retrotransposon-like gene [J]. Nat Genet, 2003,34(3):261-262.
  • 9Lujambio A, Ropero S, Ballestar E, et al. Genetic unmasking of an epigenetically silenced microRNA in human cancer cells [J]. Cancer Res, 2007,67(4):1424-1429.
  • 10Ando T, Yoshida T, Enomoto S, et al. DNA methylation of microRNA genes in gastric mucosae of gastric cancer patients: its possible involvement in the formation of epigenetic field defect [J]. Int J Cancer, 2009,124(10):2367-2374.

共引文献5

同被引文献38

  • 1Siegel RL,Miller KD,Jemal A.Cancer statistics,2015[J].CA:Cancer J Clin,2015,65 (1):25-29.
  • 2Chen K,Rajewsky N.The evolution of gene regulation by transcription factors and microRNAs[J].Nat Rev Genet,2007,8(2):93-103.
  • 3Alrfaei BM,Vemuganti R,Kuo JS.microRNA-100 targets SMRT/NCOR2,reduces proliferation,and improves survival in glioblastoma animal models[J].PloS one,2013,8 (11):e80865.
  • 4Chen P,Zhao X,Ma L.Downregulation of microRNA-100 correlates with tumor progression and poor prognosis in hepatocellular carcinoma[J].Mol Cell Biochem,2013,383 (1-2):49-58.
  • 5Oliveira JC,Brassesco MS,Morales AG,et al.MicroRNA-100 acts as a tumor suppressor in human bladder carcinoma 5637 cells[J].Asian Pacific J Cancer Prev,2011,12 (11):3001-3004.
  • 6Gebeshuber CA,Martinez J.miR-100 suppresses IGF2 and inhibits breast tumorigenesis by interfering with proliferation and survival signaling[J].Oncogene,2013,32(27):3306-3310.
  • 7Nagaraja AK,Creighton CJ,Yu Z,et al.A link between mir-100 and FRAP1/mTOR in clear cell ovarian cancer[J].Mol Endocrinol (Baltimore,Md),2010,24 (2):447-463.
  • 8Giroux V,Dagorn JC,Iovanna JL.A review of kinases implicated in pancreatic cancer[J].Pancreatology,2009,9 (6):738-754.
  • 9Yamanaka Y,Friess H,Buchler M,et al.Overexpression of acidic and basic fibroblast growth factors in human pancreatic cancer correlates with advanced tumor stage[J].Cancer Res,1993,53 (21):5289-5296.
  • 10Kuwahara K,Sasaki T,Kuwada Y,et al.Expressions of angiogenie factors in pancreatic ductal carcinoma:a correlative study with clinicopathologic parameters and patient survival[J].Pancreas,2003,26 (4):344-349.

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基础医学与临床
2015年 第4期

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