骨关节炎体外冲击波治疗的能量分布研究

Research on Energy Distribution During Osteoarthritis Treatment Using Shock Wave Lithotripsy

体外冲击波是治疗骨关节炎的一种有效方法,研究骨结构对体外冲击波治疗的影响以及进一步提高体外冲击波治疗疗效都具有重要的应用价值。本文建立了冲击波治疗骨关节炎的有限元模型,并制作人工骨结构及高速摄像系统对模型加以验证,证明所建立模型的有效性。最后利用所建的模型,预测了冲击波治疗骨关节时的能量分布。结果表明骨结构的存在会使得冲击波治疗时能量产生折射,且折射角与骨结构的位置相关。有限元方法结合磁共振/计算机断层扫描成像可以更好地保障体外冲击波治疗骨关节炎的治疗剂量及精度。

Extracorporeal shock wave treatment is capable of providing a non-surgical and effective treatment modality for patients suffering from osteoarthritis.The major objective of current works is to investigate how the shock wave（SW）field would change if a bony structure exists in the path of the acoustic wave.Firstly,a model of finite element method（FEM）was developed based on Comsol software in the present study.Then,high-speed photography experiments were performed to record cavitation bubbles with the presence of mimic bone.On the basis of comparing experimental with simulated results,the effectiveness of FEM model could be verified.Finally,the energy distribution during extracorporeal shock wave treatment was predicted.The results showed that the shock wave field was deflected with the presence of bony structure and varying deflection angles could be observed as the bone shifted up in the z-direction relative to shock wave geometric focus.Combining MRI/CT scans to FEM modeling is helpful for better standardizing the treatment dosage and optimizing treatment protocols in the clinic.