可见光和近红外荧光分光融合成像外科手术导航系统的研制

Development of a Surgical Navigation System with Beam Split and Fusion of the Visible and Near-Infrared Fluorescence

本文提出研制一种在开放手术过程中无创、实时、定位的外科手术光学导航系统。系统设计依据近红外荧光分子成像原理,采用活体荧光激发技术以及多通道分光摄像技术和图像融合软件技术。研制过程中将可见光和近红外光环形LED激发光源、多通道带通滤光片、分光摄像2CCD光电传感器和计算机系统技术集成,成功研制出一种新型外科手术光学导航系统。该系统在活体注射近红外荧光显影剂时,能够显示同一部位、同一时刻手术野组织表面的解剖学图像和近红外荧光功能图像。解决了医生在术中肉眼难以识别淋巴管、淋巴结、肿瘤边缘的技术问题,实现实时、无创的外科手术导航,有效引导外科医生切除肿瘤组织,显著提高手术成功率。该项技术已获得国家专利,专利号为ZI.2011 1 0292374.1。

This paper presents a surgical optical navigation system with non-invasive,real-time,and positioning characteristics for open surgical procedure.The design was based on the principle of near-infrared fluorescence molecular imaging.The in vivo fluorescence excitation technology,multi-channel spectral camera technology and image fusion software technology were used.Visible and near-infrared light ring LED excitation source,multi-channel band pass filters,spectral camera 2CCD optical sensor technology and computer systems were integrated,and,as a result,a new surgical optical navigation system was successfully developed.When the near-infrared fluorescence was injected,the system could display anatomical images of the tissue surface and near-infrared fluorescent functional images of surgical field simultaneously.The system can identify the lymphatic vessels,lymph node,tumor edge which doctor cannot find out with naked eye intra-operatively.Our research will guide effectively the surgeon to remove the tumor tissue to improve significantly the success rate of surgery.The technologies have obtained a national patent,with patent No.ZI.2011 1 0292374.1.