219例多囊卵巢综合征临床分析

Clinical features and pathogenesis of polycystic ovarian syndrome in 219 women

目的探讨多囊卵巢综合征(PCOS)患者的临床特点和发病机制。方法收集219例符合2003年鹿特丹诊断标准的PCOS患者,同时选取63例正常者作为对照组(N组);将PCOS患者分为两组:体重正常的PCOS患者为LP组,超重或肥胖的PCOS患者为NLP组。采集病史,进行体格检查;测定性激素及血糖、血脂等各项生化指标,进行口服糖耐量试验;最后对数据进行统计学分析。结果 1 219例PCOS患者里存在胰岛素抵抗(IR)患者[胰岛素抵抗指数(HOMA-IR)≥2.69]144例(66.36%)。2 NLP组空腹、餐后胰岛素水平升高,与N组相比差异有统计学意义(P<0.01);3 LP组促黄体生成素(LH)、睾酮(T)与N组相比增高,差异有统计学意义(P<0.05,P<0.01)。结论 IR不是PCOS发病的单纯因素,卵巢功能异常亦需关注。

Objective To investigate the clinical features and pathogenesis of polycystic ovarian syndrome （ PCOS） . Methods 219 PCOS women and 6 3 normal women were enrolled in this study as control group. 219 PCOS women were divided into lean PCOS （ LP） and non-lean PCOS groups （ NLP） . Medical history was collected and physical examinations were conducted. Sex hormones, serum glucose, blood lipid and other biochemical indexes were messured. Oral glucose tolerance tests were also done. We got the final results through analyzing statistical da-ta. Results ① The prevalence of insulin resistance （ IR） was 66. 36% in the 219 PCOS women. ② Compared with the control group, fasting and postprandial insulin level were higher in group NLP （ P〈0. 01 ） .③ In group LP, the level of LH, T were significantly increased compared with the control group （P〈0. 05,P〈0. 01）. Con-clusion IR is not a simple factor of PCOS. Attention should be paid to ovarian function abnormality at the same time.