云南省先天性唇腭裂4811例流行病学分析

Epidemiological Analysis of 4811 Patients with Chilopalatognathus in Yunnan Province

目的了解云南省唇腭裂患者的发病情况及地域特点,为云南省唇腭裂的预防和病因学研究提供依据.方法对1993年至2012年20 a间在云南省第二人民医院口腔外科手术治疗的唇腭裂4 811病例进行回顾性分析.结果在本组共4 811例病例中,唇裂1 513例,占31.4%,男1 009例,女504例,男:女=2.00:1;唇腭裂2 687例,占55.9%,单侧2 184例,双侧503例,男1 913例,女774例,男:女=2.47:1;单纯腭裂584例,占12.1%,男276例,女308例,男:女=0.90:1.云南省东部仅曲靖地区的发病较云南省其它地区高,占构成比的37.2%.病例中有遗传史者占15.6%,有环境因素影响者占32.1%.结论唇腭裂的发生可能与遗传因素、胚胎发育早期的环境因素及地域因素相关.

Objective To investigate the epid emiological characteristics of chilopalatognathus in Yunnan province, find certain related environmental factors for chilopalatognathus formation, further provide evidence for prevention and etiological research. Methods During the past twenty years from 1993 to 2012, 4811 patients with chilopalatognathus have received a primary operation in the second people＇s hospital of Yunnan province, and their clinical data were retrospectively analyzed. Results In all cases, cheiloschisis was 1513 （31.4%） , of which males and females were 1009 （21.0%） and 504 （10.4%） , respectively; cheilopalatognathus was 2687 （55.9%）, of which males and females were 1913 （39.8%） and 774 （16.1%）, respectively; cleft palate was 584 （12.1%） , of which males and females were 276 （5.7%） and 308 （6.4%） , respectively. Unilateral cleft was significantly more than bilateral cleft, and the incidence of left side was higher than that of right side. 15.6% of cases were related to heredity and 32.1% to environmental factors. There was a higher incidence in south-east of Yunnan province. Conclusion The results suggested that the occurrence of cheilopalatognathus may relate to the multiple genes and environmental factors in early stage of embryo and different areas.