绝经后骨质疏松症的T细胞亚群的变化及意义

Change and Significance of T Cell Subsets in Postmenopausal Women with Osteoporosis

目的探讨绝经后骨质疏松症女性患者外周血的T细胞亚群的改变及意义.方法流式细胞仪检测68例绝经后骨质疏松症女性及60例无骨质疏松症绝经后女性外周血的T细胞亚群,绝经后骨质疏松症女性患者外周血的T细胞亚群的改变.结果绝经后骨质疏松症女性患者外周血的T抑制/毒性淋巴细胞(Ts)比率降低,Th/Ts比值升高,NK细胞、B淋巴细胞升高(P<0.05).结论外周血的T淋巴细胞亚群的变化可能促进了OP的发生发展.NK细胞、B淋巴细胞在体液免疫、免疫应答当中也出现相应的改变,进一步加重了绝经期妇女的免疫紊乱.

Objective To investigate the change and significance of peripheral blood T cell subsets in postmenopausal women with osteoporosis. Methods Peripheral blood T cell subsets in postmenopausal women with osteoporosis （n =68） and postmenopausal women without osteoporosis （n =60） subjects were detected by flow cytometry. Results The ratio of peripheral blood T suppressor/cytotoxic lymphocytes （Ts） was decreased, while Th/Ts ratio, NK cells and B lymphocytes levels were increased in postmenopausal women with osteoporosis. Conclusion Changes in peripheral blood T lymphocyte subsets may promote the development of the osteoporosis. NK cells and B lymphocytes in humoral immune response are also changed, which can further exacerbate the immune disorder of menopausal women.