ARL15基因rs4311394多态性与非小细胞肺癌遗传易感性的关联

Association Study of ARL 15 Gene rs4311394 Polymorphisms and Genetic Predisposition of Non-small Cell Lung Cancer

目的探讨ADP-核糖基化样因子15(ADP—ribosylation factor like 15,ARL15)基因多态性与非小细胞肺癌(non-small cell lung cancer,NSCLC)的相关性.方法采用Taq Man基因分型方法对NSCLC患者(n=359)与健康体检人群(n=376)进行ARL 15基因SNP-rs4311394位点基因分型,评估这个单核苷酸多态性(single nucleotide polymorphism,SNP)与NSCLC发生的相关性,同时根据NSCLC病理类型和恶性程度进行分层分析,评估这个位点与NSCLC病理类型和恶性程度的相关性.结果 ARL15基因SNP-rs 4311394位点基因型和等位基因频率在NSCLC组和对照组中差异无统计学意义(P>0.05);在NSCLC鳞癌和腺癌中SNP-rs4311394位点基因型和等位基因频率分布差异无统计学意义(P>0.05);同时,SNP-rs4311394位点基因型和等位基因频率分布于NSCLC恶性程度也无相关性.结论 ARL15基因SNP-rs4311394与NSCLC的发生、病理类型及临床分期无相关性.

Objective This study aimed to investigate the association of polymorphisms in ARL 15 （ADP-ribosylation factor like 15） gene and non-small cell lung cancer （NSCLC） Methods 359 patients with NSCLC and 376 healthy controls in Chinese Han were included in present study. SNP-rs4311394 in ARL ]5 gene was genotyped using TaqMan technique. The correlations of the SNPs with NSCLC pathologic types and clinical stages were evaluated. Results The genotypic and allelic frequencies of SNP-rs4311394 showed no significant difference between NSCLC and the control groups （P 〉 0.05） . The genotypic and allelic frequencies of SNP-rs4311394 showed no significant difference between the squamous carcinoma and the adenoearcinoma groups （P 〉 0.05） . The genotypic and allelic frequencies of SNP-rs4311394 showed no significant difference between the stage Ⅰ＋Ⅱ and stage Ⅲ＋Ⅳ groups （P 〉 0.05）. Conclusion ARL 15 SNP-rs4311394 was not associated with the occurence, pathologic types and clinical stages of NSCLC.