摘要
目的探讨慢性阻塞性肺疾病患者SAA及IP-10与炎性因子水平相关性分析.方法选择慢阻肺患者78例,分为AECOPD组(A组)、COPD组(B组),并选择健康人群50例为对照组(C组),分别有31、47、50例,分别对各组SAA及IP-10与炎性因子进行检测.结果 A组患者SAA及IP-10水平较B、C组均出现升高(P<0.05),B组患者较C组SAA及IP-10均出现升高(P<0.05).A组患者IL-1、IL-6、TNF-α较B、C组均出现升高(P<0.05),B组患者较C组IL-1、IL-6、TNF-α均出现升高(P<0.05).SAA与IL-6、NF-α显正相关(P<0.05),与IL-1未见显著相关性(P>0.05),IP-10与IL-1、IL-6、TNF-α正相关(P<0.05).结论SAA及IP-10水平升高与炎性因子密切相关,共同参与慢阻肺患者病情进展.
Objective To investigate the correlation of SAA and IP-10 with inflammatory factors in patients with chronic obstructive pulmonary disease (COPD) Methods 78 cases of COPD patients were enrolled and divided into AECOPD group (group A, 31 cases) and COPD group (group B, 47 cases) , and 50 healthy people were chosen as control group (group C) . SAA, IP-10 and inflammatory factors were tested. Results Levels of SAA, IP-10, IL-1, IL-6 and TNF-α in group A were significant higher than those in groups B and C (P 〈 0.05) , and those in group B were significantly higher than those in group C (P 〈 0.05) . There were significant positive correlations of SAA with IL-6 and TNF- α , and of IP-10 with IL-1, IL-6 and TNF- α (P 〈 0.05) Conclusion Levels of SAA and IP-10 are closely associated with inflammatory factors, so monitoring their levels will help to make clear the progress of COPD.
出处
《昆明医科大学学报》
CAS
2015年第4期64-66,共3页
Journal of Kunming Medical University
基金
陕西省中医管理局中医药科研基金资助项目(13-JC027)