慢性阻塞性肺疾病患者SAA及IP-10与炎性因子水平相关性分析被引量：7

Correlation Analysis of SAA and IP-10 with Inflammatory Factors in Patients with Chronic Obstructive Pulmonary Disease

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摘要目的探讨慢性阻塞性肺疾病患者SAA及IP-10与炎性因子水平相关性分析.方法选择慢阻肺患者78例,分为AECOPD组(A组)、COPD组(B组),并选择健康人群50例为对照组(C组),分别有31、47、50例,分别对各组SAA及IP-10与炎性因子进行检测.结果 A组患者SAA及IP-10水平较B、C组均出现升高(P<0.05),B组患者较C组SAA及IP-10均出现升高(P<0.05).A组患者IL-1、IL-6、TNF-α较B、C组均出现升高(P<0.05),B组患者较C组IL-1、IL-6、TNF-α均出现升高(P<0.05).SAA与IL-6、NF-α显正相关(P<0.05),与IL-1未见显著相关性(P>0.05),IP-10与IL-1、IL-6、TNF-α正相关(P<0.05).结论SAA及IP-10水平升高与炎性因子密切相关,共同参与慢阻肺患者病情进展. Objective To investigate the correlation of SAA and IP-10 with inflammatory factors in patients with chronic obstructive pulmonary disease （COPD） Methods 78 cases of COPD patients were enrolled and divided into AECOPD group （group A, 31 cases） and COPD group （group B, 47 cases） , and 50 healthy people were chosen as control group （group C） . SAA, IP-10 and inflammatory factors were tested. Results Levels of SAA, IP-10, IL-1, IL-6 and TNF-α in group A were significant higher than those in groups B and C （P 〈 0.05） , and those in group B were significantly higher than those in group C （P 〈 0.05） . There were significant positive correlations of SAA with IL-6 and TNF- α , and of IP-10 with IL-1, IL-6 and TNF- α （P 〈 0.05） Conclusion Levels of SAA and IP-10 are closely associated with inflammatory factors, so monitoring their levels will help to make clear the progress of COPD.

作者贺小玉田应选

机构地区铜川矿务局中心医院呼吸内科陕西省人民医院呼吸内二科

出处《昆明医科大学学报》 CAS 2015年第4期64-66,共3页 Journal of Kunming Medical University

基金陕西省中医管理局中医药科研基金资助项目(13-JC027)

关键词血清淀粉样蛋白A 干扰素-G诱导蛋白10 慢性阻塞性肺病炎性因子 SAA IP-IO COPD Inflammatory factors

分类号 R56 [医药卫生—呼吸系统]

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1魏晋林,李盛,王宇红,朱海雪.兰州市2008～2012年居民就医住院患者疾病谱分析[J].国外医学（医学地理分册）,2013,34(4):238-241. 被引量：8
2NOWRIN K,SOHAL S S,PETERSON G,et al. Epithe- lial-mesenchymal transition as a fundamental underlying pathogenic process in COPD airways: fibrosis, remodeling and cancer [J]. Expert Rev Respir Med,2014,8 (5): 547-559.
3YOO C G, NGHIEM N P, HICKS K B, et al. Maximum pro- duction of fermentable sugars from barley straw using opti- mized soaking in aqueous ammonia (SAA) prctreatment [J]. hppl Biochem Biotechnol,2013,169 (8) : 2 430-2 441.
4TWOREK D, KUNA P, MLYNARSKI W, et al. MIG (CX- CL9), IP-10 (CXCL10) and I-TAC (CXCLI1) coneen- trations after nasal allergen challenge in patients with aller- gic rhinitis [ J ]. Arch Med Sci, 2013,9 (5) : 849- 853.
5王冬杰,霍建民.慢性阻塞性肺疾病肺功能一秒率的不同诊断标准与患者生活质量相关性[J].国际呼吸杂志,2013,33(9):671-675. 被引量：7
6DRANSFIELD M T, WILHELM A M, FLANAGAN B, et al. Acquired cystic fibrosis transmembrane conductance regu- lator dysfunction in the lower airways in COPD[J]. Chest, 2013,144(2) :498-506.
7DE CICCO F,REVERCHON E,ADAMI R,et al. In situ forming antibacterial dextran blend hydrogel for wound dressing: SAA technology vs. spray drying [ J ]. Carbohydr Polym,2014,101(2) : 1 216-1 224.
8OLSEN H G, SKOVGAARD K, NIELSEN O L, et al. Orga- nization and biology of the porcine serum amyloid A ( SAA ) gene cluster: isoform specific responses to bacterial infection [Jl. PLoS One,2013,8(10):e76 695.
9NGHIEM N P,KIM T H,YOO C G,et al. Enzymatic frac- tionation of SAA-pretreatcd barley straw for production of fuel ethanol and astaxanthin as a value-added co-product [J]. Appl Biochem Biotechnol,2013,171(2):341 -351.
10CHAEMSAITHONG P,ROMERO R,KORZENIEWSKI S J, et al. A point of care test for the determination of amni- otic fluid interleukin-6 and the ehemokine CX- CL-10/IP-IO [M]. J Matern Fetal Neonatal Med,2014: 1-10.

二级参考文献21

1于挽平,郑促伟,王平根,高允锁,罗文龙.海南省住院病人疾病谱抽样调查及疾病趋势分析[J].中国卫生统计,2006,23(3):235-236. 被引量：20
2刘秀英,刘奋忠.我县2001～2005年住院病人疾病谱变化分析[J].中国卫生统计,2007,24(3):329-330. 被引量：9
3GOLD Executive Committee. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease ( Revised 2011 ). www. goldcopd, com.
4Hansen JE, Sun XG, Wasserman K. Spirometric criteria for airway obstruction: Use percentage of FEV1/FVC ratio below the fifth percentile, not :70 %. Chest, 2007,131 : 349- 355.
5Miller MR, Hankinson J, Brusasco V, et al. Standardisation of spirometry. Eur Respir J,2005,26:319-338.
6Eric WY, David AD, Donna LM, et al. The dialysis outcomes and practice patterns study ( DOPPS ) : An international hemodialysis study. Kidney International, 2000, 57 :$74-$81.
7Pinto-Plata VM, Cote C, Cabral H, et al. The 6 rain walk distance : change over time and value as a predictor of survival in severe COPD. Eur Respir J, 2004,23 : 28-33.
8Lung function testing: selection of reference values and interpretative strategies. American Thoracic Society. Am Rev Respir Dis, 1991,144 : 1202-1218.
9Mannino DM, Sonia Buist A, Vollmer WM. Chronic obstructive pulmonary disease in the older adult:what defines abnormal lung function? Thorax, 2007,62 : 237-241.
10Global strategy for the diagnosis, management, and prevention of Chronic Obstructive Pulmonary Disease (COPD) [ Internet] [ updateted 2006 ].