肠道病毒71型VP1蛋白研究进展

Research progress of enterovirus 71 VP1

肠道病毒71型(Enterovirus71,EV71)为手足口病的主要病原体。目前,手足口病的发病机制并不完全清楚,临床上缺乏有效的疫苗及特异性治疗药物。作为EV71主要衣壳蛋白,VP1在EV71的吸附和穿入过程中起着重要作用。另一方面,VP1上存在特异性中和性抗原表位,在EV71疫苗研究中占有重要地位。本文主要概括EV71VP1结构、功能及与之相关疫苗的研究进展。

Enterovirus 71 （EV71） is a major causative factor of hand, foot and mouth disease （HFMD）. Currently, the mechanism of HFMD is not clearly understood, and neither vaccine nor antiviral therapy is available. As a capsid protein of EV71, VP1 plays an important role during the adsorption and penetration of EV71. The presence of the VPl-specific neutrali- zing epitopes makes it an important position in the EV71 vaccine research. This review article provides a summary of the struc- ture, function and associated vaccine of EV71 VP1.