女性冠状动脉慢血流与红细胞压积的相关性研究

Correlation between hematocrit and slow coronary flow in female patients

目的探讨女性冠状动脉慢血流(slow coronary flow,SCF)与红细胞压积(hematocrit,HCT)的相关性。方法169例冠状动脉狭窄【40%的女性患者,其中81例HCT】38.4%者为观察组,88例HCT≤38.4%者为对照组,比较2组临床变量。结果 2组年龄、体质量指数以及高血压病、2型糖尿病、高脂血症比率和吸烟率比较差异无统计学意义(P】0.05);相关性分析显示前降支动脉TIMI帧数(rs=0.238,P=0.002)、前降支动脉SCF的发生率(rs=0.226,P=0.003)与HCT呈正相关;多元逐步回归分析显示前降支动脉TIMI帧数(P=0.001,B=0.087,95%CI:0.039~0.135,Beta0.266)、前降支动脉SCF的发生率(P=0.001,B=1.555,95%CI:0.618~2.492,Beta0.246)与HCT独立相关。结论女性前降支动脉SCF与HCT独立相关,高水平HCT可促进SCF发生、发展。

Objective To analyze the correlation between hematocrit（HCT）and slow coronary flow（SCF）in female patients.Methods A total of 169 patients with angiographically confirmed stenosis40% were divided into observation group（n=81）（HCT〉38.4%）and control group（n=88）（HCT≤38.4%）.The clinical variables were analyzed and compared between two groups.Results There were no significant differences in the age,body mass index,hypertension,type 2diabetes mellitus,hyperlipidemia and smoking history between two groups（P〈〉.05）.The correlation analysis showed that the TIMI frame count（rs=0.238,P=0.002）and the incidence of SCF（rs=0.226,P=0.003）in the left anterior descending were positively correlated with HCT.Multivariate analyses revealed that the TIMI frame count（P=0.001,B=0.087,95%CI：0.039 to 0.135,Beta 0.266）and the incidence of SCF（P=0.001,B=1.555,95%CI：0.618 to 2.492,Beta0.246）were independently correlated with HCT.Conclusion SCF in the left anterior descending is independently correlated with HCT,which suggests that an increase in HCT may contribute to the development and progression of SCF in female patients.