摘要
他汀类药物通过抑制肝细胞内胆固醇合成,可有效降低血胆固醇特别是LDL-C浓度,延缓甚或消退动脉粥样硬化斑块,明显减少冠心病的发病率和死亡率.由于这类药物在动脉粥样硬化性心血管疾病(ASCVD)的一级和二级预防中作用十分显著,是干预血脂异常、预防ASCVD的一线基础用药,临床应用十分广泛.
出处
《中华内科杂志》
CAS
CSCD
北大核心
2015年第4期284-287,共4页
Chinese Journal of Internal Medicine
参考文献19
-
1Farmer JA. Simvastatin with or without ezetimibe in familial hypercholesterolemia (the ENHANCE trial) [J]. Curr Atheroscler Rep,2009 ,11(2) :81-82.
-
2Villines TC, Stanek EJ, Devine PJ, et al. The ARBITER 6- HALTS Trial (Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol 6-HDL and LDL Treatment Strategies in Atherosclerosis ): final results and the impact of medication adherence, dose, and treatment duration [J]. J Am Coil Cardiol,2010,55(24) : 2721-2726.
-
3Taylor A J, Villines TC, Stanek EJ. Paradoxical progression of atherosclerosis related to low-density lipoprotein reduction and exposure to ezetimibe [ J ]. Eur Heart J, 2012,33 ( 23 ) : 2939- 2945.
-
4Baigent C, Landray MJ, Reith C, et al. The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection) : a randomised placebo-controlled trial [ J ]. Lancet, 2011, 377 (9784) : 2181-2192.
-
5Huijgen R, Abbink EJ, Bruckert E, et al. Colesevelam added to combination therapy with a statin and ezetimibe in patients with familial hypercholesterolemia : a 12-week, multicenter, randomized, double-blind, controlled trial[ J]. Clin Ther, 2010, 32(4) :615-625.
-
6Yamamoto S, Tanigawa H, Li X, et al. Pharmacologic suppression of hepatic ATP-binding cassette transporter 1 activity in mice reduces high-density lipoprotein cholesterol levels butpromotes reverse cholesterol trarsport[ J]. Circulation,2011,124 (12) :1382-1390.
-
7新型调脂植物药——多廿烷醇临床应用专家共识[J].中华内科杂志,2008,47(11):961-963. 被引量:16
-
8刘顺,谭茗月,赵水平,荣惠.多廿烷醇对高脂血症患者血脂谱和血红素氧合酶1的作用[J].中华心血管病杂志,2012,40(10):840-843. 被引量:10
-
9Backes JM, Gibson CA, Ruisinger JF, et al. Modified-policosanol does not reduce plasma lipoproteins in hyperlipidemic patients when used alone or in combination with statin therapy [ J ]. Lipids ,2011,46 ( 10 ) : 923-929.
-
10AIM-HIGH Investigators, Bodcn WE, Probstfield JL, et al. Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy[J]. N Engl J Med, 2011,365(24) : 2255-2267.
二级参考文献29
-
1Singh DK, Li L, Porter TD. Policosanol inhibits cholesterol synthesis in hepatoma cells by activation of AMP-kinase. J Pharmacol Exp Ther,2006 ,318 :1020-1026.
-
2Menendez R, Fraga V, Amor AM, et al. Oral administration of policosanol inhibits in vitro copper ion-induced rat lipoprotein peroxidation. Physiol Behav, 1999,67 : 1-7.
-
3Noa M, Mas R, de la Rosa MC, et al. Effect of policosanol on lipofundin-induced atherosclerotic lesions in rats. J Pharm Pharmacol, 1995,47 : 289 -291.
-
4Noa M, de la Rosa MC, Mas R. Effect of policosanol on foam-cell formation in carrageenan-induced granulomas in rats. J Pharm Pharmacol, 1996,48:306-309.
-
5Castano G, Mas R, Fernandez L, et al. Effects of policosanol and lovastatin in patients with intermittent clandication: a double-blind comparative pilot study. Angiology, 2003,54 : 25 -38.
-
6Illnait J, Castano G, Alvarez E, et al. Effects of policosanol ( 10 mg/d) versus aspirin (100 mg/d) in patients with intermittent claudication : a 10-week, randomized, comparative study. Angiology, 2008,59 : 269 -277.
-
7Castano G, Mas R, Fernandez L, et al. Effects of policosanol on patients with borderline to mildly increased serum cholesterol levels: a prospective, double-blinded placebo-controlled study. Curr Ther Res Clin,2003 ,64 :522-537.
-
8Femandez S, Mas R, Gamez R, et al. A pharmacological surveillance study of the tolerability of policosanol in the elderly population. Am J Geriatr Pharmaeother, 2004,2:219-229.
-
9Noa M, Mendoza S, Mas R, et al. Effect of policosanol on carbon tetrachloride-induced acute liver damage in Sprague-Dawley rats. Drugs R D, 2003,4:29-35.
-
10Castano G, Mas R, Arruzazabala ML, et al. Effects of policosanol and pravastatin on lipid profile, platelet aggregation and endothelemia in older hypercholesterolemic patients. Int J Clin Pharmacol Res, 1999,19 : 105-116.
共引文献18
-
1申琳,崔君.多廿烷醇和瑞舒伐他汀治疗老年高脂血症的成本-效果分析[J].临床误诊误治,2011,24(10):87-89. 被引量:7
-
2许槟,林小娟,王梅平.多廿烷醇对老年高血压人群颈动脉内膜中层厚度的影响[J].中国医药指南,2013,11(27):143-144. 被引量:4
-
3石卫峰,归成,李晓宇,黄堃,刘皋林.上海地区119家医院2010-2012年调脂药利用分析[J].中国药房,2014,25(6):500-503. 被引量:2
-
4欧阳克氙,刘建平,蔡力创.天然活性物质调控鸡蛋胆固醇的研究进展[J].江西科学,2014,32(6):829-832.
-
5丁宇,司全金.多廿烷醇在老年心血管病患者调脂治疗中的有效性及安全性分析[J].中华老年心脑血管病杂志,2015,17(6):575-579. 被引量:12
-
6张冲,邬丹莲.我院内分泌科糖尿病患者调脂药物使用情况分析[J].临床合理用药杂志,2015,8(34):115-116. 被引量:2
-
7中国成人血脂异常防治指南(2016年修订版)[J].中华心血管病杂志,2016,44(10):833-853. 被引量:967
-
8诸骏仁,高润霖,赵水平,陆国平,赵冬,李建军.中国成人血脂异常防治指南(2016年修订版)[J].中国循环杂志,2016,31(10):937-953. 被引量:3066
-
9中国成人血脂异常防治指南(2016年修订版)[J].中华全科医师杂志,2017,16(1):15-35. 被引量:288
-
10陈华凝,练桂丽,许昌声,谢良地.多廿烷醇对野百合碱诱导的肺动脉高压大鼠肺动脉重构的影响[J].中华高血压杂志,2016,24(12):1135-1141. 被引量:1
同被引文献18
-
1吴文静,柯元南.华法林与氯沙坦、非诺贝特及别嘌醇伍用致上消化道出血[J].药物不良反应杂志,2005,7(1):59-60. 被引量:3
-
2Introduction[J]. Diabetes Care, 2015,38 Suppl:S1-S2.
-
3Handelsman Y, Bloomgarden ZT, Grunberger G, et al. American association of clinical endocrinologists and american college of endocrinology-clinical practice guidelines for developing a diabetes mellitus comprehensive care plan-2015[J]. Endocr Pract,2015,21 Suppl 1:1-87.
-
4Stone NJ, Robinson JG, Lichtenstein AH, et al.2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults : a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines[J]. J Am Coll Cardiol,2014,63(25 Pt B):2889-2934.
-
5Meek C, Wierzbicki AS,Jewkes C,et al. Daily and intermittent rosuvastatin 5 mg therapy in statin intolerant patients : an observational study[J]. Curr Med Res Opin, 2012,28(3):371-378.
-
6ACCORD Study Group,Ginsberg HN,Elam MB, et al. Effects of combination lipid therapy in type 2 diabetes mellitus[J]. N Engl J Med,2010,362(17);1563-1574.
-
7Ziaeian B, Dinkier J, Watson K. Implementation of the 2013 American College of Cardiology/American Heart Association Blood Cholesterol Guideline Including Data From the Improved Reduction of Outcomes : Vytorin Efficacy International Trial[J]. Rev Cardiovasc Med, 2015 , 16(2):125-130.
-
8Jones PH,Davidson MH. Reporting rate of rhabdomyolysis with fenofibrate + statin versus gemfibrozil + any statin[J]. Am J Cardiol,2005,95(1):120-122.
-
9AIM-HIGH Investigators, Boden WE, Probstfield JL, et al. Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy[J]. N Engl J Med,2011,365(24):2255-2267.
-
10Rajpathak SN,Kumbhani DJ,Crandall J,et al. Statin therapy and risk of developing type 2 diabetes : a meta-analysis[J]. Diabetes Care,2009,32(10):1924-1929.
二级引证文献4
-
1汪晓楠,崔世磊,江汉秋,王佳伟.血糖和血脂异常代谢与糖尿病性眼肌麻痹患者的关联分析[J].临床眼科杂志,2016,24(6):485-487. 被引量:1
-
2陈俊.非他汀类药物治疗血脂异常[J].中华内科杂志,2017,56(3):176-178. 被引量:5
-
3肖幸,周仑,高翔,张存泰,凃玲.41例服用华法林老年患者国际标准化比值异常变化的药物因素[J].医药导报,2018,37(1):107-109. 被引量:8
-
4庄红焰.血脂检验在糖尿病患者临床诊断中的意义分析[J].临床检验杂志(电子版),2019,8(3):101-102. 被引量:6
-
1血脂异常老年人使用他汀类药物中国专家共识[J].中华内科杂志,2015,54(5):467-477. 被引量:90
-
2李云,常海凤.他汀类调脂药的药理及临床[J].青岛医药卫生,2003,35(4):292-293.
-
3知名药师解答“三高”用药[J].首都医药,2010(19):58-58.
-
4陆勤燕.他汀类调脂药物临床应用进展[J].中国疗养医学,2002,11(4):32-33.
-
5赵俊英.前列地尔注射液治疗老年糖尿病肾病40例疗效分析[J].吉林医学,2011,32(32):6807-6808. 被引量:5
-
6郭丹杰.他汀类药物致横纹肌溶解症1例[J].临床药物治疗杂志,2009,7(4):51-53. 被引量:1
-
7侯中宁.低分子肝素联合硝酸甘油治疗不稳定型心绞痛41例疗效观察[J].中国伤残医学,2012,20(3):54-55.
-
8他汀类调脂药物可能有助抗癌[J].家庭用药,2012(11):7-7.
-
9张绘莉,赵水平.他汀类调脂新药:西立伐他汀[J].世界医学杂志,1999,3(12):72-75.
-
10孙秀波,穆林,何祎晨,邓丽华,刘蕾.2013年全国6个地区他汀类调脂药物使用分析[J].中国新药杂志,2015,24(9):1074-1080. 被引量:4