贲门失弛缓症发病机制的研究进展

Pathogenesis of achalasia

贲门失弛缓症(achalasia)是一种食管运动障碍性疾病,其主要特征是吞咽时食管蠕动停止,食管下括约肌(low esophageal sphincter,LES)松弛障碍.原发性贲门失弛缓症主要是由于食管肌间神经丛抑制性神经纤维缺乏所引起的.但是,本病的确切发病机制仍未明确,本文就关于贲门失弛缓症发病机制的文献进行了回顾.

Achalasia is a kind of esophageal motility disorder, and it is mainly characterized by loss of the peristalsis of the esophagus during swallowing and insufficient lower esophageal sphincter（LES） relaxation. Primary achalasia is mainly due to the lack of inhibitory nerve fibers in the esophageal myenteric nerve plexus. However, the exact pathogenesis of the disease is still clear. This paper reviews recent progress in understanding the pathogenesis of achalasia.