N-末端脑钠素原和超敏C反应蛋白在小儿支原体肺炎并心肌损害中的应用分析

The application of NT-ProB NP and hs-CRP in patients suffered children mycoplasma pneumonia combined with myocardial damage

目的分析N-末端脑钠素原(NT-Pro BNP)和超敏C反应蛋白(hs-CRP)在小儿支原体肺炎并心肌损害中的应用价值。方法将我院确诊MPP并心肌损害71例患儿根据NYHA心功能分级标准,分为心功能Ⅰ级A组19例,心功能Ⅱ级B组18例,心功能Ⅲ级C组18例,心功能Ⅳ级D组16例,比较其c Tn I、CK-MB、Hs-CRP和NT-Pro BNP差异,并比较心功能Ⅳ级组未治疗、治疗7 d、15 dc Tn I、CK-MB、Hs-CRP和NT-Pro BNP差异。结果 B组c Tn I、Hs-CRP和NT-Pro BNP水平高于A组;C组c Tn I、CK-MB、Hs-CRP和NT-Pro BNP水平高于A组和B组;D组c Tn I、CK-MB、Hs-CRP和NT-Pro BNP水平高于A组、B组和C组;治疗7 d时c Tn I、CK-MB、Hs-CRP和NT-Pro BNP结果入院时明显降低,治疗15 d时c Tn I、Hs-CRP和NTPro BNP结果较入院时及治疗7 d时明显降低,其CK-MB结果较入院时检查有差异(P均<0.05)。结论NT-Pro BNP和hs-CRP是小儿肺炎支原体肺炎并心肌损害安全、有效、全面的检查手段。

Objective This article was to analyze the application efficacy of NT-ProBNP and hs-CRP in children suffered mycoplasma pneumonia combined with myocardial damage.Methods According to NYHA cardiac functional grading standards,the 71 cases of children with mycoplasma pneumonia and myocardial damage were divided into group A（ Heart function at grade I, 19 cases） ,group B （ Heart function at grade II, 18 cases） , group C （ Heart function at grade III, 18 cases） and group D （ Heart function at grade IV, 16 cases） .Theconcentration of cTnI, CK-MB, hs-CRP and NT-proBNP were detected and compared. The changes of concentration of cTnI,CK-MB,hs-CRP and NT-proBNP in group D were compared.Results The concentration of cTnI、Hs-CRP and NT-ProBNP in group B were higher than that in group A.The concentration of cTnI、CK-MB、Hs-CRP and NT-ProBNP in group C were higher than that in group A and B.The concentration of cTnI、CK-MB、Hs-CRP and NT-ProBNP in group D were higher than those in group A, B and C.The concentration of cTnI、CK-MB、Hs-CRP and NT-ProBNP of group D after 7 days been treated were lower than those untreated.The concentration of cTnI、CK-MB、Hs-CRP and NT-ProBNP of group D after 15 days been treated were lower than those at 7th day been treated and untreated,CK-MB decreased compared with the concentration when patients were hospitalized （P〈0.05）.Conclusions NT-ProBNP and hs-CRP are safe, effective and comprehensive inspection means in diagnose children mycoplasma pneumonia combined with myocardial damage.