草酸艾司西酞普兰联用坦度螺酮治疗广泛性焦虑障碍的临床观察

Clinical observation on escitalopram oxalate tandospirone treatment of patients with generalized anxiety dwasorder

目的评价草酸艾司西酞普兰联用坦度螺酮对广泛性焦虑障碍患者治疗的临床疗效和安全性。方法将62例符合入组标准的广泛性焦虑障碍患者随机分为坦度螺酮联合草酸艾司西酞普兰治疗组(31例)和草酸艾司西酞普兰对照组(31例),治疗8周。采用汉密尔顿焦虑量表(HAMA)、不良反应量表(TESS)评定疗效及副反应。结果两组治疗后HAMA评分均较治疗前明显下降(P均<0.01);联用治疗组起效快,在第1、2、4、6、8周末时HAMA评分显著低于对照组(P均<0.05);联用治疗组优于对照组,但两组疗效在8周末疗效差异比较无显著性(P>0.05);两组不良反应差异比较无显著性(P>0.05)。结论坦度螺酮联合草酸艾司西酞普兰可明显改善焦虑症状,起效明显且安全性好。

Objective Evaluation of escitalopram oxalate tandospirone on clinical efficacy and safety of the treatment of patients with generalized anxiety dwasorder.Methods 62 patients met the inclusion criteria for patients with generalized anxiety dwasorder were randomly divided into tandospirone combined with escitalopram oxalate treatment group （31 cases） and oxalic acid Ai Sciplan control group （31 cases） , treatment for 8 weeks. The Hamilton Anxiety Scale （ HAMA） and the adverse reactions scale （ TESS） to evaluate the efficacy and side reaction.Results Two groups after treatment HAMA score were significantly decreased than before treatment （P〈0.01）;combined treatment group effect soon, in first, 2, 4, 6, 8 over the weekend when the HAMA score was significantly lower than the control group （ all P〈0.05）; combined treatment group than in control group, but the effect of the two groups in the 8 weekend effect difference compared no significant difference between two groups （P 〉0.05）; there was no significant adverse reaction （P 〉0.05）.Conclusions Tandospirone combined with escitalopram oxalate can obviously improve the symptoms of anxiety;the effect is obvious and safe.