摘要
目的探讨质子泵抑制剂引发骨质疏松的病变机制和治疗措施。方法 60例采取质子泵抑制剂治疗的消化系统疾病患者作为研究对象,根据患者的具体情况选择合适的药物,主要有钙剂和维生素D制剂。骨密度T值≤2.5者加用抗骨质疏松药物。结果经过治疗,患者髋关节和腰椎骨密度T值均有显著性上升(均P<0.01)。结论对于长期服用质子泵抑制剂的患者来说,有必要定期检测骨密度,同时给予预防性治疗,以降低骨折风险。
Objective To study the pathological changes mechanism of osteoporosis caused by proton pump inhibitors and treatment measures.Methods 60 cases treated with proton pump inhibitors in patients with diseases of the digestive system as the research object, according to the specific condition of patients to choose the appropriate drugs, mainly with calcium and vitamin D preparation.Bone mineral density T values add anti osteoporosis drugs 2.5 or less.Results After treatment, patients with hip and T value （density were significantly increased （P〈0.01）.Conclusions For patients with long-term use of proton pump inhibitors, periodic testing bone mineral density;it is necessary to give preventive treatment at the same time in order to reduce the risk of fractures.
出处
《齐齐哈尔医学院学报》
2015年第8期1154-1155,共2页
Journal of Qiqihar Medical University
关键词
质子泵抑制剂
骨质疏松
病变机制
治疗
Proton pump inhibitor
Osteoporosis
Lesions mechanism
Treatment
