期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

BDNF rs6265和COMT rs4680与广西壮族散发性帕金森病的相关性研究 被引量：2

Association study between rs6265 and rs4680 on sporadic Parkinson's disease in Zhuang population
下载PDF
导出
摘要 目的:探讨脑源性神经营养因子(BDNF)rs6265和儿茶酚胺氧位甲基转移酶(COMT)rs4680的多态性与广西壮族散发性帕金森病(PD)的相关性。方法:使用PCR-RFLP法对112例壮族散发性PD患者的rs6265和rs4680位点进行基因分型,并与156例健康壮族老年人比较,分析这两个多态与PD的相关性。结果:除PD早发亚组rs6265基因型GG的频率高于同年龄段对照组(P<0.05),两组间的等位基因及基因型频率均无统计学差异(P>0.05)。两位点A等位基因罹患PD的风险与正常人群无异,OR分别为1.212(P=0.572)和0.985(P=0.427)。结论:rs6265和rs4680与广西壮族散发性PD的遗传易感缺乏关联性。 Objectives：To investigate the correlation between BDNF rs6265 and COMT rs4680 on sporadic Parkinson＇s disease（PD）in Zhuangs.Methods：PCR-RFLP was employed to genotype rs6265 and rs4680for112sporadic PD patients and 156 controls.Results：No difference on allelic and genotypic frequencies was found between the two groups（all P〉0.05）under any genetic models except that the GG genotype of rs6265 was higher in the early-onset PD subgroup as compared to controls（P〈0.05）.Similar PD risk for A and non-A allele carriers was found on both SNP（rs6265：OR = 1.212,P = 0.572;rs4680：OR = 0.985,P = 0.427）.Conclusions：No association between rs6265 and rs4680and the susceptibility of sporadic PD in Zhuangs.
作者 梁庆华 庞国防 吕泽平 胡才友 黄东挺 周博峰 黄春丽 余天智 唐凤川 葛琳 潘尚领 彭均华
机构地区 广西壮族自治区江滨医院 广西医科大学病理生理学教研室
出处 《陕西医学杂志》 CAS 2015年第4期419-420,共2页 Shaanxi Medical Journal
基金 国家自然科学基金项目(31160209) 广西自然科学基金项目(2011GXNSFA018278)
关键词 帕金森病 脑源性神经营养因子 @儿茶酚胺氧位甲基转移酶 Parkinson disease Brain-derived neurotrophic factor @COMT
分类号 R742.5 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献6

  • 1Egan MF,Kojima M,Callicott J,et al.The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function[J].Cell,2003,112(2),257-269.
  • 2Chen J,Lipska BK,Halim N,et al.Functional analysis of genetic variation in catechol-O-methyltransferase(COMT):effects on mRNA,protein,and enzyme activity in postmortem human brain[J].Am J Hum Genet,2004,75(5):807–821.
  • 3Guerini F,Beghi E,Riboldazzi G,et al.BDNF Val66Met polymorphism is associated with cognitive impairment in Italian patients with Parkinson’s disease[J].Eur J Neurol,2009,16(11):1240-1245.
  • 4Lee YH,Song GG.BDNF 196G/A and 270C/T polymorphisms and susceptibility to Parkinson's disease:a meta-analysis[J].J Mot Behav,2014,46(1):59-66.
  • 5梁庆华,庞国防,韦勇,胡才友,吴巾,刘承武,潘尚领,彭均华.BDNF Val66Met多态性与长寿群体代谢综合征危险因素的相关性研究[J].临床检验杂志,2014,32(10):736-740. 被引量：4
  • 6Jiménez-Jiménez FJ,Alonso-Navarro H,García-Martín E,et al.COMT gene and risk for Parkinson's disease:a systematic review and meta-analysis[J].Pharmacogenet Genomics,2014,24(7):331-339.

二级参考文献11

  • 1Chaldakov G. The metabotrophic NGF and BDNF : an emerging concept [J]. Arch Ital Biol, 2011,149(2) :257-263.
  • 2Han JC,Liu QR,Jones M, et al. Brain-derived neurotrophic factor and obesity in the WAGR syndrome [ J] . N Engl J Med,2008,359(9):918-927.
  • 3Pan SL, Luo XQ, Lu ZP, et al. Microsomal triglyceride transfer protein gene -493 G/T polymorphism and its association with serum lipid levels in Bama Zhuang long-living families in China [ J ]. Lipids Health Dis, 2012, 11:177.
  • 4Sheikh HI, Hayden EP, Kryski KR, et al. Genotyping the BDNF rs6265 ( val66met ) polymorphism by one-step amplified refractory mutation system PCR[ J]. Psychiatr Genet, 2010, 20(3) :109-112.
  • 5Zhao X,Xi B,Shen Y, et al. An obesity genetic risk score is associated with metabolic syndrome in Chinese children[ J]. Gene, 2014, 535(2):299-302.
  • 6HongKW, Lim JE, Go MJ, et al. Recapitulation of the association of the Val66Met polymorphism of BDNF gene with BMI in Koreans [J]. Obesity(Silver Spring) , 2012,20(9) :1871-1875.
  • 7Krabbe KS, Nielsen AR, Krogh-Madsen R, et al. Brain-derived neurotrophic factor( BDNF) and type 2 diabetes [ J]. Diabetologia, 2007, 50(2) : 431438.
  • 8Ma XY, Qiu WQ, Smith CE, et al. Association between BDNF rs6265 and Obesity in the Boston Puerto Rican Health Study [J]. J Obes, 2012, 2012:102942.
  • 9DuSfitkovdL,Zamrazilovd H, Sedl6Ckov6 B, et al. Association of obesity susceptibility gene variants with metabolic syndrome and related traits in 1,443 Czech adolescents [ J ]. Folia Biol ( Praha),2013,59(3) :123-133.
  • 10王洁,吕泽平,胡才友,刘承武,彭均华,黄龄瑾,罗晓秋,潘尚领.广西巴马地区壮族长寿家系血糖状况分析[J].广西医科大学学报,2011,28(1):55-57. 被引量：3

共引文献3

同被引文献22

  • 1Wu Q,Chen L,Zheng Y,et al.Cognitive impairment is common in Parkinson's disease without dementia in the early and middle stages in a Han Chinesecohort[J].Parkinsonism Relat Disord,2012,18(2):161-165.
  • 2Janvin C,Aarsland D,Larsen JP,et al.Neurophychological Profile of patients with Parkinson's disease without dementia[J].Dement Geriatr Cogn Disord,2003,15(3):126.
  • 3Haber SN,Calzavara R.The cortico-basal ganglia integrative network:the role of the thalamus[J].Brain Res Bull,2009,78(2-3):69-74.
  • 4Emre M.What causes mental dysfunction in Parkinson's disease[J].Mov Disord,2003,18(Suppl 6):S63-71.
  • 5Sagar HJ,Sullivan EV,Gabrieli JDE,et al.Temporal ordering and short-term memory deficits in parkinson’s disease[J].Brain,2003,101:325-339.
  • 6Bonnie EL,Maria ML,William.Cognitive impairments associated with early Parkinson’s disease[J].Neurology,2002,39:557.
  • 7Melzer TR,Watts R,Macaskill MR,et al.White matter microstructure deteriorates across cognitive stages in Parkinson disease[J].Neurology,2013,80:1841-1849.
  • 8Lee SJ,Kim JS,Lee KS,et al.The severity of leukoaraiosiscorrelates with the clinical phenotype of Parkinson's disease[J].Arch Gerontol Geriatr,2009,49(2):255-259.
  • 9Slaughter JR,Slaughter KA,Nichols D,et al.Prevalence,clinical manifestations,etiology,and treatment of depression in Parkinson's disease[J].J Neuropsychiatry Clin Neurosci,2001,13(2):187.
  • 10Levy G,Schupf N,Tang MX,et al.Combined effect of age and severity on the risk of dementia in Parkinson's disease[J].Ann Neural,2002,51(3):722.

引证文献2

二级引证文献2

陕西医学杂志
2015年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部