动物源性抗氧化肽的生物学功能及与其结构的关系

Biological Functions of Animal-Derived Antioxidative Peptides and Its Relationship with the Peptides Structure

氧化应激是诱导脂质腐败、促使细胞凋亡、导致组织损伤及病变的主因。摄入适量抗氧化剂可有效清除体内过剩的自由基,防止脂质过氧化,保护线粒体的正常结构和功能,进而降低腹水综合征、癌症、动脉硬化、糖尿病等疾病的发病率。作为一种天然抗氧化剂,动物源性抗氧化肽由于其原料来源广、安全性高、易吸收等特性而成为国内外研究的热点。本文针对动物源性抗氧化肽的种类、结构及其生物学功能的研究状况进行综述,重点探讨抗氧化活性肽的生物学功能及与其结构的关系,并就目前抗氧化肽研究的难点及其在医药、食品等领域中的应用前景做了分析和展望。

Oxidative damage induced by oxygen radicals is the major factor to accelerate apoptosis and to make tissue damage and to suffer from diseases. Using antioxidants is effective for scavenging excess free radicals, preventing lipid peroxidation, protecting the natural structure and function of mitochondria, and further reduc-ing morbidity of cancer, arteriosclerosis, diabetes and so on. As one type of natural antioxidants, animal-de-rived antioxidative peptides have become the hotspot for its abundant sources, high safety and absorption easily. This paper summarized species, structure and biological functions of animal-derived antioxidative peptides. It also put emphasis on discussing the functional properties and relationship between the structure and the func-tions, analyzing the difficulties of current antioxidant peptide researches and further predicting its application prospects in the field of medicine and food as well as animal feeding.