冠心病患者肺炎衣原体感染炎症因子与血脂的水平

Chlamydia pneumoniae infection,inflammatory factor and blood lipid level in patients with coronary heart disease

目的:探讨冠心病患者肺炎衣原体感染阳性率,炎症因子与血脂的水平。方法:选择我院的冠心病患者50例作为冠心病组,同期在门诊就诊的非冠心病患者33例作为非冠心病对照组,比较两组肺炎衣原体(Cpn)IgG阳性率,血脂和炎症因子的水平。结果:与非冠心病对照组比较,冠心病组血脂中TC[(3.96±1.07)mmol/L比(4.75±1.33)mmol/L]、TG[(1.05±0.42)mmol/L比(1.67±0.82)mmol/L]、LDL-C[(2.12±0.47)mmol/L比(2.88±0.86)mmol/L]水平明显升高(P均<0.05);炎性因子C-反应蛋白[CRP,(3.85±0.87)mg/L比(5.80±1.60)mg/L]、白介素-6[IL-6,(6.50±1.53)mg/L比(15.80±7.62)mg/L]、肿瘤坏死因子-α[TNF-α,(5.50±1.60)mg/L比(16.10±2.20)mg/L]明显升高(P均<0.05);冠心病组血清中Cpn IgG抗体阳性率明显高于非冠心病对照组(78.0%比21.2%,P<0.05)。结论:本组冠心病患者肺炎衣原体阳性率炎症因子与血脂水平显著上升,感染与血脂异常可能有协同作用,共同引起冠心病发生发展。

Objective：To explore the Chlamydia pneumoniae （Cpn） immunoglobulin （Ig） G positive rate , inflamma‐tory factors and blood lipid levels in patients with coronary heart disease （CHD） .Methods ：A total of 50 CHD patients hospitalized in our hospital were selected as CHD group ,and 33 non‐CHD patients visited to outpatient clinic in same period were regarded as non‐CHD control group .Blood lipid ,inflammatory factor levels ,and positive rate of Cpn IgG were compared between two groups .Results ：Compared with non‐CHD control group ,there were significant rise in levels of TC [ （3.96 ± 1.07） mmol/L vs .（4.75 ± 1.33） mmol/L] ,TG [ （1.05 ± 0.42） mmol/L vs .（1.67 ± 0.82） mmol/L] and LDL‐C [ （2.12 ± 0.47） mmol/L vs .（2.88 ± 0.86） mmol/L] , P 〈 0.05 all ;significant rise in levels of inflammatory factor ：C reactive protein [CRP ,（3.85 ± 0.87） mg/L vs .（5.80 ± 1.60） mg/L] ,interleukin‐ 6 [IL‐6 ,（6.50 ± 1.53） mg/L vs .（15.80 ± 7.62） mg/L] and tumor necrosis factor‐α [TNF‐α ,（5.50 ± 1.60） mg/L vs .（16.10 ± 2.20） mg/L] in CHD group , P 〈 0.05 all ;positive rate of serum Cpn IgG in CHD group was significantly higher than that of non‐CHD control group （78.0% vs .21.2% ,P 〈 0.05） .Conclusion ： In present study ,positive rate of serum Cpn IgG ,inflammatory factor and blood lipid levels significantly rise in CHD patients ; Chlamydia pneumoniae infection and dyslipidemia may have a synergistic effect ,cause occurrence and development of CHD in common .