摘要
目前研究表明,移植到梗死心肌的骨髓间充质干细胞(BM-MSCs)有大量死亡,效果不理想。微小RNAs是一类非编码单链小分子RNA,在许多方面参与BM-MSCs移植治疗心肌梗死治疗过程。本文主要从微小RNAs生物学功能及对BM-MSCs分化与旁分泌的调控作用方面,概述微小RNAs在BM-MSCs移植治疗心肌梗死中的作用。
Current researches indicate that transplanted BM‐MSCs accompanies massive death ,and its effect is unsat‐isfactory .The miRNAs are a class of small non‐coding single‐stranded RNA molecules ,involve therapeutic course of bone marrow mesenchymal stem cell treating myocardial infarction in many respects .The present article made an o‐verview on effect of microRNAs in transplanted BM‐MSCs treating myocardial infarction via mainly illustrating bio‐logical function of microRNAs and its regulation effect on BM‐MSCs differentiation and paracrine secretion .
出处
《心血管康复医学杂志》
CAS
2015年第2期210-213,共4页
Chinese Journal of Cardiovascular Rehabilitation Medicine
基金
国家自然科学基金(3001-30400432)~~
关键词
微RN
A
s
骨髓祖代细胞
心肌梗死
MicroRNA
Myeloid progenitor cells
Myocardial infarction
