Kupffer细胞在乙肝和丙肝病毒感染中的作用机制

Role of Kupffer Cells in Hepatitis B or C Virus Infections

乙肝病毒或丙肝病毒（hepatitis B virus or hepatitis C virus, HBV/ HCV）感染是肝脏慢性疾病最常见原因。 Kupffer 细胞（KC）定植于肝血窦中,是机体数量最多的内脏巨噬细胞,在 HBV/ HCV 病毒感染后肝脏慢性炎症疾病发展中扮演了极为重要的角色。 KC 通过各种信号通路影响细胞因子的分泌及细胞间作用,调节着机体的炎性反应和免疫活动。它的激活决定着炎症和抗炎的平衡,维持机体的内环境的稳态。研究 KC 对了解肝脏 HBV/ HCV 感染的致病机制及治疗有重要意义。

Hepatitis B or C virus （HBV/ HCV） infections are the most common cause of chron-ic liver disease. Kupffer cells （KCs）, located in the hepatic sinusoid, are the visceral macrophages of greatest number, and they play an extremely important role in the development of liver chronic inflammation after HBV/ HCV infection. KCs affect the secretion of cytokines and interaction between cells through a variety of signaling pathways, and regulate the inflammatory response and immune activity. The activation of KC is the key to the balance of inflammation and anti-inflammation, and it maintains the stability of the internal environment. Studies on KC are of great importance for the un-derstanding of the pathogenic mechanisms and treatment of HBV/ HCV infections.