超声引导下无水乙醇和奥沙利铂联合注入晚期肝癌的疗效观察

Curative effect observation of injection of ethanol with oxaliplatin under ultrasound-guided in advanced liver cancer

目的观察超声引导下无水乙醇和奥沙利铂联合对晚期肝癌瘤内注入的疗效。方法选取我院肿瘤科失去外科治疗意义的39例晚期肝癌患者,在实时超声引导下对肝内瘤体行无水乙醇和奥沙利铂联合注入,观察患者生活质量改善情况、瘤体大小改变、血清甲胎蛋白水平变化和1、2、3年的存活率。结果在完成治疗2周后,33例患者生活质量有明显改善,11例患者肝内瘤体改变获益,31患者血清甲胎蛋白水平明显下降;术后1、2、3年的存活率分别为66.7%、35.9%、12.8%。结论超声引导下对晚期肝癌患者行瘤体内无水乙醇和奥沙利铂联合注入治疗效果良好,对于改善该类患者的生活质量、延长存活率有积极意义。

Objective To observe the effect of injection of ethanol with oxaliplatin under ultrasound-guided in advanced liver cancer. Methods Thirty-nine patients with advanced liver cancer who lost meaning of surgery were retrospectively analyzed,the injection of ethanol with oxaliplatin under real-time ultrasound-guided into liver tumors was performed,the improvement of quality of life,the change of tumors size,alphafetoprotein（AFP） level in serum and survival rate of 1,2,3 years were observed. Results After 2 weeks＇ treatment, the quality of life in 33 patients had improved significantly, 11 cases of liver tumors was benifit from the tumor change,31 patients with serum AFP level were decreased siguifieantly,the survival rate of 1,2,3 years was 66.7%, 35.9%, 12.8% respectively. Conclusion Effect of injection of ethanol with oxaliplatin under ultrasound-guided in advanced liver cancer is good, it could improves the quality of life and prolong the survival rate in these patients.