摘要
目的探讨粉尘螨口服滴剂的抗过敏作用特点。方法采用豚鼠回肠平滑肌过敏收缩实验和肺支气管灌注法观察粉尘螨口服滴剂对平滑肌的抑制作用 ;大鼠被动皮肤过敏反应观察其对血管通透性改变的影响和颅骨骨膜法观察其对肥大细胞脱颗粒的抑制作用。结果粉尘螨口服滴剂能够明显抑制回肠平滑肌和拮抗抗原对支气管平滑肌的收缩作用 ,对肥大细胞脱颗粒具有显著的抑制作用。
Aim The oral drops of dermatophagoides farinae for the inhibition of allergy was studied. Methods The effects of the drops of dermatophagoides farinae on the constraction of the ileum smooth muscle and the bronchoalveolar smooth muscle stimulated by antigen in guinea pigs, and on the mastocyte degranulation and the change of the vessel penetrability in rats were observed with the methods of the skull bone membrane and rat passive cutaneous anaphylaxis (PCA). Results The oral drops of dermatophagoides farinae can inhibit significantly the constration of ileum smooth muscle and brachoalveolalr smooth muscle, the mastocyte degranulation, and the release of transmitters.Conclusion The oral drops of dermatophagoides farinae has significant inhibition to allergy.It can be used to treat allergic asthma and other allergic disease.
基金
江西省科委资助项目
