抗病毒药物治疗慢性乙型肝炎的临床进展

Clinical progression of treatment of chronic hepatitis B with antiviral drugs

慢性乙型肝炎是乙型肝炎病毒(hepatitis B virus,HBV)引起的传染性疾病,会导致肝功能严重受损,控制不及时还会导致肝硬化、重症肝炎等病变,严重威胁患者的生命健康。目前,抗病毒疗法是治疗慢性乙型肝炎的主要方法,而干扰素、多糖类化合物和核苷酸类似物是主要的抗病毒药物。本文就慢性乙型肝炎的现状、抗HBV药物和治疗方案作一综述。

Chronic hepatitis B is an infectious diseases which caused by hepatitis B virus. The virus impairs liver func-tion and, if it is not controlled timely, causes cirrhosis and fulminant hepatitis which threats the health of patients serious-ly. Antiviral therapy is the main method for treatment of chronic hepatitis B at present, while interferon, polysaccharide compounds and nucleotide analogues are the main antiviral drugs. This paper reviews the status of chronic hepatitis B, an-tiviral drugs and treatment protocol of chronic hepatitis B.