病毒性脑炎患儿血清高敏心肌肌钙蛋白T和心肌酶变化及其临床意义

Changes and significance of serum high sensitive myocardial troponin T and myocardial enzymes in children with viral encephalitis

目的探讨病毒性脑炎患儿血清心肌酶和高敏心肌肌钙蛋白T(hs-cTnT)检测及其临床意义。方法采用全自动生化检测仪测定病毒性脑炎患儿(脑炎组,42例)和同期住院非脑炎患儿(对照组,38例)血清hs-cTnT和AST、乳酸脱氢酶(LDH)、肌酸激酶(CK)和CK同工酶(CK-MB)。结果脑炎组血清hs-cTnT和AST、LDH、CK、CK-MB均高于对照组(P<0.01)。脑炎组血清hs-cTnT和AST、LDH、CK-MB异常发生率均高于对照组(P<0.01)。结论病毒性脑炎患儿存在不同程度的心肌损害。血清hs-cTnT及心肌酶学检测对病毒性脑炎合并心肌损害或心肌炎有较高的早期诊断价值。

Objective To investigate the changes and significance of serum high sensitive myocardial troponin T（hs-cTnT）and myocardial enzymes in children with viral encephalitis.Methods Serum levels of hs-cTnT,AST,lactate dehydrogenase（LDH）,creatine kinase（CK）and CK-muscle brain isozyme（CK-MB）were measured with fully automatic biochemical detector in 42 children with viral encephalitis（group A）and 38 children without viral encephalitis（group B）.Results Serum levels of hs-cTnT,AST,LDH,CK and CK-MB were all higher in group A than those in group B（P〈0.01）.The percentages of children with abnormal serum hs-cTnT,AST,LDH and CK-MB were all higher in group A than those in group B（P〈0.01）.Conclusion The children with viral encephalitis have a certain degree myocardial damage.Detection of serum hs-cTnT,AST,LDH,CK and CK-MB is helpful in the early diagnosis of myocardial damage and myocarditis in children with viral encephalitis.