1215例葡萄膜炎患者葡萄膜炎类型与病因分析探讨

Clinical characteristics of 1215 cases with uveitis

目的分析探讨葡萄膜炎的类型以及可能的病因。方法回顾性分析2009年9月至2014年9月就诊于吉林大学第二医院眼底病内科的1215例葡萄膜炎患者的临床资料。患者病史资料采集完整，相关辅助检查完善。根据解剖位置，将其表现分为前葡萄膜炎、全葡萄膜炎、中间葡萄膜炎和后葡萄膜炎。根据患者一般资料和临床辅助检查结果，分析患者年龄、性别、葡萄膜炎类型，探讨可能的病因。结果1215例患者中，男性587例，占48．31％；女性628例，占51．69％。男女比例为0．93：1。发病年龄4～91岁，平均发病年龄（41．43±14．20）岁。发病年龄〈20岁83例，男性40例，女性43例，男女比例为0．93：1；21～50岁808例，男性412例，女性396例，男女比例为1．04：1；〉50岁324例，男性135例，女性189例，男女比例为0．71；1。表现为前葡萄膜炎572例，占47．08％；全葡萄膜炎527例，占43．37％；中间葡萄膜炎52例，占4．28％；后葡萄膜炎64例，占5．27％。能够明确葡萄膜炎病因、类型者703例，占57．86％；不能明确葡萄膜炎病因、类型者512例，占42．14％。能够明确葡萄膜炎病因、类型的703例患者中，伏格特一小柳一原田（VKH）综合征、强直性脊椎炎伴发的葡萄膜炎、BehCet病分别占30．44％、19．77％、14．22％，位列能够明确葡萄膜炎病因、类型患者的前3位。结论本组葡萄膜炎患者男女比例为0．93：1，平均发病年龄（41．46±14．20）岁。VKH综合征、强直性脊椎炎伴发的葡萄膜炎和Behcet病是其常见的葡萄膜炎类型。

Objective To analyze the clinical character of uveitis in second hospital of Jilin university. Methods Retrospectively analyze the clinical data of uveitis patients referred to from Second Hospital of Jilin University from September 2009 to September 2014. According to anatomical location, the manifestation of these uveitis patients were divided into anterior uveitis, panuveitis, intermediate uveitis and posterior uveitis. To discuss the possible causes of these patients according to the general information and relevant clinical laboratory examinations results. Results There were 1215 cases in this study, which included 587 male, accounting for 48.31%; and 628 female, accounting for 51.69M. The ratio of male-to- female was 0.93：1. The range of the age of these patients was from 4 to 91 years old. The mean age of these patients at the onset of these disease was （41.43±14.20） years. Of the 1215 cases, 40 male and 43 female were younger than 20 years. The ratio of male-to-female was 0.93：1; 412 male and 396 female were between 21 and 50 years old. The ratio of male-to-female was 1.04： 1; 135 male 189 female were older than 50 years. The ratio of male-to-female was 0.71：1. There were 572 cases of anterior uveitis, accounting for 47.08% ; 527 cases of panuveitis, accounting for 43.37% ; 52 cases of intermediate uveitis, accounting for 4.28% ; 64 cases of posterior uveitis, accounting for 5.27%. 703 cases had etiological diagnosis according to the clinical character and the auxiliary results, accounting for 57.68%. Vogt-koyanagi Haradal （VKH） syndrome, ankylosing spondylitis associated with uveitis and Behcet＇s disease were the common entity, accounting for 30.44%, 19.77% and 14.22% respectively. Conclusions The mean age of these patients in this study was older, compared to other reports. Female patients were more than male, especially in these patients older than 50 years. VKH syndrome, ankylosing spondylitis associated with uveitis and Behcet＇s disease were the common entities.