银杏内酯联合甲钴胺治疗糖尿病周围神经病变的疗效观察

The Effi cacy of Ginkgolide with Methylcobalamin in Treating Diabetic Peripheral Neuropathy

目的:观察银杏内酯联合甲钴胺治疗糖尿病周围神经病变(DPN)的疗效。方法:93例DPN患者随机分为两组,观察组46例给予银杏内酯6 m L加入0.9%氯化钠注射液250 m L静脉滴注1次/d,甲钴胺片0.5 mg,口服,3次/d;对照组47例单用甲钴胺片0.5 mg,口服,3次/d,两组疗程均为2周,对比两组临床疗效及神经症状改善情况。结果:观察组总有效率为97.83%,对照组总有效率为82.98%,观察组治疗总有效率显著高于对照组;两组治疗前神经症状评分无统计学意义(P>0.05),治疗后神经症状评分均显著低于治疗前,且观察组神经症状评分显著低于对照组组间比较,差异具有统计学意义(P<0.05)。结论:银杏内酯联合甲钴胺片治疗DPN的疗效优于单用甲钴胺片。

Objective To observe the clinical effects of ginkgolide with methylcobalamin in treatment of diabetic peripheral neuropathy. Methods 93 patients with diabetic peripheral neuropathy were randomly divided into 2 groups, the experimental group with 46 cases were treated with ginkgolide 0.6 m L, one time/day and methylcobalamin tablets 0.5 mg three times/day; the control group with 47 cases were treated with methylcobalamin tablets 0.5 mg three times/day. Electromyography and transcutaneous oxygen tensionmeasurements were observed before and after two weeks treatment. Two groups＇ clinical curative effect and the neurological symptoms were compared and analyzed. Results The total effective rate of observation group was 97.83%, for the control group was 82.98%, which showed the observation group was signifi cantly higher than that in control group; the nerve symptom scores did not differ significantly between the two groups before treatment, while the score of neural symptoms were signifi cantly lower than that before treatment, and the observation group of nerve symptom score was signifi cantly lower than that of control group. Conclusion Ginkgolide with methylcobalamin treatment of diabetic peripheral neuropathy is better than the singleuse of methylcobalamin.