大连市2011-2013年发热伴血小板减少综合征布尼亚病毒监测分析

Fever with thrombocytopenia syndrome bunya virus Surveillance analysis in Dalian during 2011-2013

目的研究大连市2011-2013年发热伴血小板减少综合征布尼亚病毒（SFTSV）流行病学特点及感染状况,为制定防控策略提供依据。方法采用PCR-荧光探针法进行血清标本的检测。采用Excel电子表格进行资料整理及SPSS 13.0进行数据分析。结果 2011-2013年共检测标本111份。2011-2013年的发热伴血小板减少核酸检测阳性率分别为35.71%（10/28）、37.04%（10/27）、58.93%（33/56）,合计为47.75%（53/111）。经显著性检验,差异有统计学意义（χ2趋势=4.79,P=0.03﹤0.05）,发热伴血小板减少核酸检测阳性率有逐年上升趋势。病例以农民为主,发病无性别差异,年龄以50~79岁组为主,6~10月份为高发季节,瓦房店、庄河、普兰店为疾病高发地区。结论大连市是发热伴血小板减少综合征布尼亚病毒流行地区,标本的及时检测对病例治疗有重要作用。农民是主要宣传保护对象。本地病毒宿主等病毒相关研究需持续开展。

Objective To study the epidemiological characteristics and infection situation of the fever with thrombocytopenia syndrome bunya virus in Dalian from 2011 to 2013,and to provide evidence for prevention and control strategy. Methods Using PCR fluorescence probe method for detection of serum specimen. Using the Excel spreadsheet data compilation and SPSS13. 0 for data analysis. Results Specimens of the 111 cases from2011 to 2013 were tested. In 2011,2012,2013,fever with thrombocytopenia nucleic acid testing positive rate was 35. 71%（ 10 /28）,37. 04%（ 10 /27）,58. 93%（ 33 /56） respectively; Combined was 47. 75%（ 53 /111）. Difference was statistically significant（ χ2t r e n d= 4. 79,P = 0. 03 ﹤ 0. 05）,fever with thrombocytopenia nucleic acid testing positive rate has a rising trend year by year. Cases is given priority to with farmers,no gender differences,age is given priority to with 50 to 79,June-October were peak season,Wafangdian,Zhuanghe and Pulandian were high-risk areas. Conclusions Dalian is epidemic areas of fever with thrombocytopenia syndrome bunya virus,specimen timely detection play an important role in cases treatment. Farmers are the main propaganda protection object. Viruses such as the local host research need to be sustained.