扶正清瘿法对甲状腺球蛋白抗体和甲状腺过氧化物酶抗体的影响

Serum thyroglobulin antibody and thyroid peroxidase antibody levels in patients with autoimmune thyroid disease receiving Traditional Chinese Medicine Fuzheng Qingying therapy

目的探讨扶正清瘿法对自身免疫性甲状腺疾病患者血清Tg-ab和Tpo-ab的影响。方法选取96例血清Tg-ab和Tpo-ab增高的患者,分别以中医辨证施治(中医组),采用扶正清瘿法为主治疗,及中西医结合治疗(中西组)和单纯西医治疗(西医组),观察疗效结果。结果 3组患者症状和体征评分均较治疗前降低,差异有统计学意义(P<0.01);中医组、中西组、西医组分别有45、39、12例抗体下降,有效率分别为88.89%、76.92%、50%。治疗前后,中医组血清Tg-ab和Tpo-ab明显下降(P<0.05),中西组和西医组Tg-ab和Tpo-ab差异无统计学意义(P>0.05)。结论扶正清瘿法具有明显的改善自身免疫性甲状腺疾病的症状和体征,能有效地降低血清Tg-ab和Tpo-ab的水平,纠正和改善甲状腺的功能。

Objective To investigate the efficacy of Traditional Chinese Medicine Fuzheng Qingying therapy for patients with autoimmune thyroid disease. Methods Ninety six patients with autoimmune thyroid disease were treated with Traditional Chinese Medicine（ TCM） Fuzheng Qingying therapy（ TCMgroup,n = 45）,combination of TCMwith Western medicine（ combination group,n = 39） or Western medicine（ western group,n = 12）. Serum thyroglobulin antibody（ Tg-ab） and thyroid peroxidase antibody（ Tpo-ab） levels were measured before and after treatment. Results Compared to pretreatment levels the signs and symptoms scores of all 3 groups were decreased after treatment（ P〈0. 01）. The response rates of TCMgroup,combination group and western group were 88. 9%,76. 9%and 50. 0%,respectively. Serum Tg-ab and Tpo-ab levels in TCMgroup were significantly decreased after treatment（ P〈0. 05）, but not decreased in combination and western groups.Conclusion Traditional Chinese Medicine Fuzheng Qingying therapy can significantly improve the signs and symptoms, and effectively decrease serum Tg-ab and Tpo-ab levels in patients with autoimmune thyroid disease.