摘要
Dear Editor,Although various components of the Wnt/β-catenin pathway have been investigated,there are conflicting reports on the roles of Wnt/β-catenin signaling in oligodendrogenesis and differentiation.For instance,theΔExon3 mutation ofβ-catenin[1-4],which stabilizesβ-catenin by deletion of the phosphorylation site for the destruction complex,signifi cantly inhibits the differentiation of oligodendrocytes,
Dear Editor, Although various components of the Wnt/β-catenin pathway have been investigated, there are conflicting reports on the roles of Wnt/β-catenin signaling in oligodendrogenesis and differentiation. For instance, the △Exon3 mutation of β-catenin[14], which stabilizes β-catenin by deletion of the phosphorylation site for the destruction complex, significantly inhibits the differentiation of oligodendrocytes, but knockout of β-catenin also delays it.
基金
supported by the National Basic Research Development Program of China (2013CB531303, 2012CB910402)
the National Natural Science Foundation of China (31101642, 31372150)
the Science and Technology Key Project of Zhejiang Province, China (2011C13030)
the National Institutes of Health, USA (R01-NS37717)
