胃黏膜上皮内瘤变的研究进展

Progress in research of gastric intraepithelial neoplasia

胃癌是一种全球高发的消化系恶性肿瘤,早期胃癌的诊断是胃癌防治的要点.而胃黏膜上皮内瘤变作为胃癌的癌前病变始终是国内外研究的焦点.为了探索二者之间的关系,近年来,胃黏膜上皮内瘤变的相关领域、诸多方面都有较多研究进展,包括分子遗传学水平相关基因、癌基因改变;在临床处理方面的根除幽门螺杆菌(Helicobacter pylori,H.pylori)、定期随访和内镜治疗等,这些都为今后的临床工作带来一定的指导意义.但对胃黏膜上皮内瘤变的产生、影响因素和怎样演变为胃癌仍存在着很大疑问和未知领域,这需要进行大量多中心、较长期、前瞻性的设计研究.

Gastric carcinoma is one of the most common malignant tumors in the world,and the accurate diagnosis of precancerous lesions plays an important role in gastric cancer prevention.Intraepithelial neoplasia is a form of precancerous lesion of gastric cancer,and many efforts have been done to explore the relationship between gastric cancer and dysplasia.Recently,there has been much progress in the research of intraepithelial neoplasia,including genetic changes at the molecular level,the eradication of Helicobacter pylori（H.pylori）,regular follow-up and endoscopic therapy.All of these will play an important role in clinical management of this condition.However,the etiological mechanism,influencing factors and malignant transformation of GIN are still unclear.Hence,further multi-center and long-term prospective studies are needed to solve these problems.