水貂阿留申病抗体检测技术研究及应用进展

Research into the Antibody Detection Technology of Mink Plasmacytosis and Its Current Applications

水貂阿留申病严重危害毛皮动物产业发展,其病毒中和抗体不能提供保护能力,相反可造成水貂持续性感染,迄今尚无特异的防治方法。因此世界各国主要通过抗体检测技术筛选并淘汰阳性水貂以达到阿留申病的净化清除。本文介绍了阿留申抗体检测的经典技术,常规检测技术对流免疫电泳及一些有潜在应用价值的新兴技术,并对其发展趋势做了展望。

Mink plasmacytosis, caused by Aleutian Mink Disease Virus （AMDV）, poses a threat to the development of the animal fur industry. Neutralizing antibodies against AMDV may result in a persistent infection rather than providing protection for minks. To date, no specific methods to prevent or cure this disease have been developed. In order to eliminate mink plasmacytosis, antibody detection technology has been used globally as a dominant approach to screen for AMDV-positive minks. This paper introduces the classical technology, counterimmunoelectrophoresis and emerging technology in terms of AMDV antibody detection, and provides a glimpse into the future development of these technologies.