生长因子应用于慢性牙周炎位点保存的临床观察

The clinical observation of applying growth factors to site preservation in chronic periodontitis

目的:观察重度慢性牙周炎患者分别使用富血小板纤维蛋白(platelet-rich fibrin,PRF)和碱性成纤维细胞生长因子(basic fibroblast growth factor,b FGF)行拔牙窝位点保存的临床疗效。方法:29例重度慢性牙周炎患者随机分为3组,患牙拔除后,牙槽窝行位点保存术:PRF组牙槽窝行位点保存术使用患者自身血液离心制备的PRF;b FGF组使用b FGF;空白对照组不使用PRF或b FGF。术后6个月后观察临床疗效。结果:使用生长因子PRF或b FGF的患者术后6个月观察,牙龈形态饱满,骨高度保持,骨密度增加。未使用PRF或b FGF生长因子的患者骨密度较低。结论:牙周炎患者位点保存术中使用生长因子PRF和b FGF可以有效改善软硬组织的情况,保存更多的牙槽骨量。

Objective：To observe the clinical effect of site preservation using platelet-rich fibrin or basic fibroblast growth factor in patients who suffer from serious chronic periodontitis. Method：Twenty nine patients were divided into three groups. Teeth of patients were extracted,tooth sockets were did site preservation technique：PRF group was used platelet-rich fibrin which was made from blood of patients. bFGF group was used basic fibroblast growth factor. Control group did not use PRF or bFGF. After six months,the clinical effect of three groups was observed. Result：After six months,patients of PRF group and bFGF group were observed that bone have sufficient bone height and mineral density has increased. Bone density of patients who did not use growth factors is low. Conclusion：Using growth factor such as platelet-rich fibrin or basic fibrob-last growth factor can improve the condition of soft and hard tissue,and can maintain more bone mass in ridge preservation of serious chronic periodontitis.