胸腺活化调节趋化因子17和CC趋化因子受体4与不明原因复发性流产的相关性研究

Relationship between human activation regulated chemokine ligand 17/CC chemokine receptor 4 and unexplained recurrent spontaneous abortion

目的:探讨血清中胸腺活化调节趋化因子17(CCL17)与CC趋化因子受体4(CCR4)水平与不明原因复发性流产的关系。方法:选取健康早孕女性(HEP组)、健康未孕女性(HNP组)和不明原因复发性流产孕妇(URSA组)各50例,采用ELISA法测定血清中CCL17与CCR4浓度。结果:HEP组中CCL17、CCR4水平显著高于URSA组和HNP组,且差异具有统计学意义(P<0.05);URSA组中的CCL17、CCR4水平高于HNP组,但差异无统计学意义(P>0.05)。结论:不明原因复发性流产患者血清中CCL17与CCR4的水平较正常妊娠妇女显著降低,提示CCL17和CCR4与不明原因复发性流产的发生具有相关性,且有望成为判断不明原因复发性流产发生的新的参考指标。

Objective： To explore the relationship of human activation regulated chemokine ligand 17 （CCL 17） and CC chemokine receptor 4 （CCR4） in serum with unexplained recurrent spontaneous abortion （URSA）.Methods： Healthy pregnant women （HEP group）, healthy nonpregnant women （HNP group） and unexplained recurrent spontaneous abortion of pregnant women （URSA group） were collected with 50 cases each. The concentrations of serum CCL17 and CCR4 were tested by ELISA. Results： The concentrations of serum CCL17 and CCR4 of HEP group were higher than those of URSA group and HNP group （P〈0.05）. The concentration of serum CCL17 and CCR4 of URSA group were higher than those in HNP group, but the difference was not statistically significant （P〉0.05）. Conclusion： The concentrations of serum CCL17 and CCR4 of URSA group were lower than those in HEP group, which suggested that the correlation held in the CCL17/CCR4 and URSA, and the CCL17/CCR4 was expected to become a new reference index in the URSA.