摘要
目的:评价黄体酮肌肉注射和阴道缓释凝胶(Crinone 8%)2种给药途径对体外受精-胚胎移植(IVF-ET)结局的影响。方法:计算机检索Pub Med、EMbase、Cochrane图书馆、中国知网和万方。收集2种给药途径的随机对照试验(RCT),提取有效数据后采用Rev Man 5.1软件进行Meta分析。结果:纳入10个随机对照试验,共计2 528例患者,其中肌肉注射组1 331例,阴道缓释凝胶组1 197例。Meta分析结果显示:阴道缓释凝胶组和肌肉注射组的临床妊娠率(OR=0.93,95%CI=0.79-1.09,P=0.35)、继续妊娠率(OR=0.88,95%CI=0.64-1.21,P=0.43)、流产率(OR=0.75,95%CI=0.52-1.08,P=0.12)无统计学差异。结论:黄体酮肌肉注射和阴道缓释凝胶对IVF-ET后的临床妊娠率、继续妊娠率及流产率无显著影响。
Objective: To evaluate the effect of Crinone vaginal gel and intramuscular (IM) progesterone for luteal phase support (LPS) in in vitro fertilization-embryo transfer (IVF-ET) with respect to clinical outcomes. Methods: Papers from PubMed, EMbase, Cochrane library, CNKI and Wanfang data were electronically searched. Randomized controlled trials (RCT) were identified about vaginal gel and IM progesterone for LPS in IVF-ET. Date were extracted from these trials and analyzed by RevMan 5.1 software. Results: A total of 10 RCTs involving 2 528 cases were included, of which 1 331 cases were in Crinone 8% group while the other 1 197 cases were in IM group. Meta analysis showed a comparable effect between vaginal gel and IM progesterone on the end points of clinical pregnancy rate (OR=0.93, 95%CI=0.79-1.09, P=0.35), ongoing pregnancy rate (OR=0.88, 95%CI=0.64- 1.21, P=0.43) and miscarriage rate (OR=0.75, 95%CI=0.52-1.08, P=0.12). Conclusion: There is no significant difference between vaginal gel and im progesterone in terms of clinical pregnancy rate, ongoing pregnancy rate and miscarriage rate.
出处
《生殖与避孕》
CAS
CSCD
北大核心
2015年第4期252-258,共7页
Reproduction and Contraception
基金
浙江省自然科学基金项目(LY13H040005)
浙江省医药卫生科技计划项目(2014KYA115)