摘要
目的:探讨含ω-3多不饱和脂肪酸(PUFA)的肠外营养对胃癌病人免疫功能的影响。方法:计算机检索1996年1月至2014年5月国内外数据库中研究择期手术后补充ω-3 PUFA对胃癌病人免疫功能影响的文献,同时进行手工检索和参考文献回溯。采用偏倚风险评估标准对纳入随机对照试验的质量进行评价。采用RevMan 5.1软件进行Meta分析,研究ω-3 PUFA对胃癌病人免疫功能(Ig A,Ig G,Ig M,CD4,CD8,CD4/CD8)的影响。结果:共检索到1 176篇相关文献,剔除数据重复、抄袭和无法获得方法学资料的文摘,最终纳入5个随机对照研究,共计217例病人。Meta分析结果显示,含ω-3 PUFA的肠外营养与对照组比,CD4/CD8、CD4、Ig G、Ig A、Ig M等差异均有统计学意义。结论:适当剂量和一定干预时间的ω-3 PUFA能增强胃癌病人应激状态下的免疫功能。
Objective： To investigate the effects of ω-3 polyunsaturated fatty acids （PUFA）in parenteral nutrition on immune function in patients with gastric cancer. Methods： We searched the study from January 1996 to May 2014 about supplemental ω-3 PUFA on immune function in patients with gastric cancer. Results： A total relevant documents retrieved 1 176, exclude duplication of data, plagiarism, and unable to obtain information on the metholdology abstracts, eventuually included five radomized study, atotal of 217 cases of patients. Meta-analysis showed that the immune function （IgA, IgG, IgM, CD4, CD8, CD4/CD8） was imported and the differences between groups were statistically signif- icant. Conclusion： The co-3 polyunsaturated fatty acids can enhance the immune function in patients with gastric cancer.
出处
《肠外与肠内营养》
CAS
北大核心
2015年第2期107-111,共5页
Parenteral & Enteral Nutrition
关键词
Ω-3多不饱和脂肪酸
肠外营养
胃癌
免疫功能
META分析
ω-3 polyunsaturated fatty acids
Parenteral nutrition
Gastric cancer
Immunefunction
Meta analyses
