摘要
cAMP反应元件结合蛋白（cAMP-responsive element bindingprotein，CREB）作为转录因子，促进启动子中具有cAMP反应元件（cAMPresponseelement，CRE）的基因转录。近年的研究显示，CREB转录共激活因子（CREB-regulated transcription coactivator,CRTC；又名transducer of regulated CREB，TORC）家族可以显著增强CREB靶基因的转录。CRTC家族有3个成员（CRTC1-3），其中CRTC1在脑组织中高表达。一些研究表明CRTC1在神经元树突生长发育、长时程突触可塑性、记忆巩固和再巩固等过程中发挥重要作用；且在神经退行性相关疾病等发病过程中出现表达或活性异常。本文主要针对CRTC1表达或活性异常在神经退行性相关疾病发病过程中的作用及分子机制做一综述。
The cAMP-responsive element binding protein （CREB）-regulated transcription coactivator, CRTC （also known as transduc- er of regulated CREB, TORC）, is identified as a potent modulator of cAMP response element （CRE）-driven gene transcription. The CRTC family consists of three members （CRTC1-3）, among which the CRTC1 shows the highest expression in the brain. Several studies have demonstrated that the CRTC1 plays critical roles in neuronal dendritic growth, long-term synaptic plasticity, memory consolidation and reconsolidation etc., whereas dysfunction of CRTC1 is mainly involved in neurodegenerative disorders. In light of these findings, we aim to review recent research reports that indicate the CRTC1 dysfunction and its underlying mechanisms in the neurodegenerative disorders.
出处
《生理学报》
CAS
CSCD
北大核心
2015年第2期155-162,共8页
Acta Physiologica Sinica
基金
supported by the National Natural Science Foundation of China(No.81171036,81371224)
the Open Research Fund of State Key Laboratory of Bioelectronics,Southeast University,China(No.G7)
