静脉注射免疫球蛋白对神经病理性疼痛治疗作用的研究进展

Research progress of therapy of intravenous immunoglobulin on neuropathic pain

静脉注射免疫球蛋白具有多种免疫调节方面的功能,临床上常用于自身免疫性疾病的治疗。近年来,静脉注射免疫球蛋白也应用于许多神经系统疾病的治疗,因为部分神经系统疾病的发病机制与免疫调节相关。神经病理性疼痛是慢性顽固性的疼痛综合征,发病机制复杂,免疫调节也参与神经病理性疼痛的发生。目前发现静脉注射免疫球蛋白可以明显减轻神经病理性疼痛患者的疼痛,给药后无严重不良反应的发生,而且在镇痛的同时可以促进伤口的愈合,提高患者的生活质量。其作用机制可能是免疫球蛋白可以阻断自身抗体与Fc受体结合或中和自身抗体,减轻补体介导的组织损伤作用;还可以通过降低炎性细胞因子表达减轻患者的疼痛。

Intravenous use of immunoglobulin exhibits many immuno-modulatory properties and has been used clinically to treat several autoimmune disease.Currently,immunoglobulin is being investigated as an immuno-modulatory therapy in many neurological diseases.Neuropathic pain is choronic intractable pain syndrome,which has complex mechanisms,immuno-modulatory involved.Recently,intravenous immunoglobulin has significant antinocicetptive effect on neuropahtic pain patients,without any serious adverse reactions.It improves functional recovery,and quality of life.The mechanism may be blocking immunoglobulin binding with Fc receptor or neutralizing antibodies to reduce the damage of complement-mediated;may also reduce inflammatory cytokines in patients with neurological disease.