β-异硫氰酸苯乙酯多靶向抗肿瘤作用机制研究进展

Advances in multi-targeted anti-tumor mechanisms ofβ-phenethyl isothiocyanate

全球癌症的发病率逐年攀升,癌症治疗已成为科学界和医学界的重要研究课题。β-异硫氰酸苯乙酯(phenethyl isothiocyanate,PEITC)来源于十字花科植物,是广泛被研究的异硫氰酸酯(isothiocyanate,ITC)家族成员之一。越来越多流行病学和病理学研究证实PEITC可以诱导肿瘤细胞周期阻滞和凋亡。PEITC通过调节多种分子机制实现其抗肿瘤作用。本文对这些相关文献进行分析整理,对PEITC药物多靶向抗肿瘤作用机制和潜在的分子靶点进行简要综述。

Cancer has very high mortality and increasing prevalence rates.And cancer therapy has become an important research topic in the scientific community and the medical profession.Phenethyl isothiocyanate（PEITC）is one of the most widely investigated isothiocyanates from the crucifers.Increasing evidences from epidemiological and pathological studies suggest that PEITC can induce cancer cell cycle arrest and apoptosis.It exerts its chemopreventive effect through regulation of diverse molecular mechanisms.Here,we summarize recent data regarding the multi-targeted anti-cancer activity mechanisms and potential molecular targets of PEITC.