丹酚酸B在心血管疾病中药理作用研究进展

Research progress of salvianolic acid B in cardiovascular diseases

心血管疾病严重威胁人类的健康和生活质量,目前已成为导致人类死亡的头号杀手。因此,寻找有效的治疗药物以降低该病的致死率和致残率成为亟待解决的问题。丹参因其具有较好的活血化瘀功效,目前已被广泛的用于心血管疾病的治疗且取得较好的疗效。丹酚酸B是丹参提取物中的主要水溶性成分之一,研究证实丹酚酸B具有多种药理活性,不仅对心肌梗死(myocardial infarction,MI)具有很好的保护作用,同时也能够明显的改善心肌缺血/再灌注(myocardial ischemia-reperfusion,MI/R)的损伤。该文就近年来丹酚酸B在心血管疾病中的药理研究进展进行综述,阐述丹酚酸B调控心血管疾病的药理作用机制及其与心血管疾病治疗的关系,为丹酚酸B的临床应用及后续研究提供参考。

Cardiovascular disease is a serious threat to human health and quality of life,and it has become the leading cause of death in human. Thus,looking for effective drugs to reduce the mortality and morbidity of such a disease has become a problem to be solved. Due to its good efficacy of activating blood circulation and dissipating blood stasis,salvia miltiorrhiza has been widely used in the treatment of cardiovascular disease and obtained a good curative effect. Salvianolic acid B is one of the main water-soluble components of salvia miltiorrhiza extract and studies have shown that salvianolic acid B possesses many biological activities,which not only has a good protective effect on my-ocardial infarction,but could significantly alleviate myocardial ischemia-reperfusion injury. This article reviews the research progress of salvianolic acid B in cardiovascular diseases,and also includes discussion about the mechanisms of salvianolic acid B in the regulation of cardiovascular diseases,which may provide references for follow-up research and clinical treatment.