半胱氨酸天冬氨酸特异性酶-1诱导的Pyroptosis及其在感染性疾病中的作用

Caspase-l-induced Pyroptosis and its role in infectious diseases

半胱氨酸天冬氨酸特异性酶-1（Caspase-1）的激活可诱导细胞通过一种称为Pyroptosis的方式死亡。Pyroptosis是一种程序性细胞死亡方式，其形态学特征有别于细胞凋亡或坏死，主要表现为包膜破裂，胞内容物外流。在许多感染性疾病中，Caspase-1诱导产生的细胞因子和细胞死亡可促进机体清除病原体；但在一些病原体感染中，Caspase-1活化引起的炎症反应和细胞死亡可能和病原体的致病机制有关。此文就细胞Pyroptosis时的形态学特征、机制及其在感染性疾病中的作用进行综述。

Activated caspase-1 can induce cell death through a method called Pyroptosis which is a procedural method of cell death. Its morphological feature is different from cell apoptosis or necrocytosis, which appears to be membranolysis and outflow of cellular content. In a range of infections, caspase-l-dependent cell death and cytokine production are likely to work together to promote effective pathogen clearance and can benefit the host; but in certain infections, they may contribute to the pathogenesis of pathogens. This article focuses on the morphological feature and mechanism during Pyroptosis, and its effect on infectious disease.