地塞米松和甘油在细菌性脑膜炎中的应用

Advances on dexamethasone and glycerol as adjunctive therapy in bacterial meningitis

尽管使用高效的抗菌药物，但细菌性脑膜炎至今仍有较高的发病率和病死率。研究显示其不良预后与蛛网膜下腔的炎症反应有关，因此阻止脑膜炎早期瀑布样炎症反应将有助于改善细菌性脑膜炎的临床预后。此文就地塞米松和甘油作为细菌性脑膜炎的辅助治疗进展作一综述。

Bacterial meningitis is associated with high morbidity and mortality despite the availability of effective antibiotics. Experimental studies showed that the inflammatory response in the subarachnoid space is associated with unfavorable outcome. The use of adjuvant therapy in bacterial meningitis draws its rationale from the notion of arresting the inflammatory cascade at an early stage of the disease to improve clinical outcome. This paper reviews advances in dexamethasone and glycerol as adjunctive therapy in bacterial meningitis.