镁合金可降解血管支架发展历史与研究现状

The History and Development of Biodegradable Magnesium Alloy Stents

血管内支架是治疗心脑血管狭窄性疾病最有效的方法之一,裸金属支架易导致血管再狭窄,药物洗脱支架面临迟发性支架内血栓和延长双重抗血小板治疗的问题。生物可降解血管支架理论上克服了永久性支架的缺点,提供临时血管支撑,在完成治疗任务后降解吸收。镁合金因其良好的生物相容性和可降解性成为目前可降解血管支架的研究热点。基础和临床研究证实镁合金支架安全、有效,有望替代永久性支架。本文就可降解血管支架特点、镁合金支架研究现状及面临的挑战进行综述。

Stenting is one of the most effective ways to treat atherosclerosis cardiovascular and cerebrovascular diseases . Bare metal stents easily lead to restenosis .Drug‐eluting stents are faced with the challenges of late stent thrombosis and the requirement for extended dual antiplatelet therapy . Bioabsorbable stents have been introduced to potentially to overcome these limitations ,as they provide temporary scaffolding and then disappear .Because of its good biocompatibility and biodegradability ,magnesium alloy has been becoming a research hotspot of biodegradable stents . The safety and effectiveness of magnesium alloy stents have been proven by basic and clinical researches and the stents are expected to replace permanent metal ones .In this article we review the advantages and current status of biodegradable magnesium alloy stents and the further challenges that remain .