尼莫地平联合前列地尔治疗2型糖尿病周围神经病变疗效观察

Curative effect observation of nimodipine combined with alprostadil in the treatment of type 2 diabetic peripheral neuropathy

目的评价尼莫地平联合前列地尔治疗2型糖尿病周围神经病变的临床疗效和安全性。方法 64例2型糖尿病周围神经病变患者随机分为治疗组和对照组,各32例;在综合治疗基础上,治疗组给予尼莫地平联合前列地尔注射液;对照组仅给予前列地尔注射液,治疗4周。观察治疗前后两组的神经症状和体征评分、肌电图神经传导速度变化;观察药物的不良反应。结果两组均能有效降低神经症状和体征评分,增加神经传导速度,但治疗组优于对照组(P<0.05);两组均无明显不良反应;治疗组总有效率优于对照组(P<0.05)。结论尼莫地平联合前列地尔治疗糖尿病周围神经病变,安全有效。

Objective To evaluate the clinical effect and safety of nimodipine combined with alprostadil in the treatment of type 2 diabetic peripheral neuropathy. Methods A total of 64 patients with type 2 diabetic peripheral neuropathy were randomly divided into treatment group and control group, with 32 cases in each group. On the basis of comprehensive treatment, the treatment group received nimodipine combined with alprostadil injection, and the control group was given alprostadil injection alone. The treatment lasted for 4 weeks, and observation was made on neurological and physical signs scores, changes of electromyography nerve conduction velocity, and adverse drug reactions of the two groups before and after treatment. Results Both groups had lowered neurological and physical signs scores, and increased nerve conduction velocity, while those were better in the treatment group than the control group（P〈0.05）. Both group had no obvious adverse reactions. The treatment group had better total effective rate than the control group（P〈0.05）. Conclusion Combination of nimodipine and alprostadil injection is safe and effective in treating diabetic peripheral neuropathy.