糖尿病足溃疡时血小板聚集、释放和膜糖蛋白Ⅵ变化的临床研究

Clinical research of platelet aggregation, release and change of membrane glycoprotein Ⅵ in diabetic foot ulceration

目的研究糖尿病足溃疡患者血小板聚集、释放和膜糖蛋白Ⅵ(GPⅥ)的变化。方法 42例2型糖尿病患者按有无糖尿病足分为:非糖尿病足(DM)组(未患糖尿病足)17例和糖尿病足(DFU)组25例;同时选取15例健康志愿者为对照组。检测空腹血糖值、糖化血红蛋白、血小板聚集率、血小板P选择素释放和血小板GPⅥ阳性率。结果 DFU组空腹血糖值和糖化血红蛋白(Hb A1c)两项指标均高于对照组(P<0.05);DFU组血小板聚集率显著高于对照组与DM组(P<0.05);DFU组血小板P选择素释放高于对照组与DM组(P<0.05);DFU组的GPⅥ阳性率高于对照组和DM组,差异均具有统计学意义(P<0.05)。结论血小板功能的变化可能与糖尿病足的发病有关。

Objective To research platelet aggregation, release and change of membrane glycoprotein Ⅵ in diabetic foot ulceration. Methods A total of 42 patients with type 2 diabetes mellitus were divided into non diabetic foot（DM）group（without diabetic foot） with 17 cases and diabetic foot（DFU） group with 25 cases. Another 15 healthy volunteers were selected as control group. Detection was made on fasting blood-glucose, glycosylated hemoglobin, platelet aggregation rate, platelet P-selectin release, and platelet GP Ⅵ positive rate. Results DFU group had higher indexes of fasting blood-glucose and glycosylated hemoglobin（Hb A1c） than the control group（P〈0.05）. DFU group had higher platelet aggregation rate than the control group and DM group（P〈0.05）. DFU group had higher platelet P-selectin release than the control group and DM group（P〈0.05）. DFU group had higher GP Ⅵ positive rate than the control group and DM group, and the differences had statistical significance（P〈0.05）. Conclusion Change of platelet function have relationship with the progress of diabetic foot.